Boštjan Korenjak (Author), Vladimira Erjavec (Author), Veronika Kralj-Iglič (Author)

Abstract

Extracellular nanoparticles (EPs) in blood have been amply studied since their biological role was indicated more than 50 years ago. Among the various types of nano-sized blood constituents, the studies outlined lipoproteins, immune complexes and extracellular particles. Efforts have been invested to separate or separately assess different types of particles. Recently, much attention has been devoted to extracellular vesicles (EVs), however, experimental evidence indicates that the methods used for their harvesting and assessment importantly influence the content of the samples whereas the information on characteristics of the samples that could reflect the clinical status of the sample donor may be altered. Recent developments of the characterization methods point to the possibility of assessing nano-sized EPs directly in plasma and blood, thereby avoiding artefacts caused by processing. In this contribution, we consider the assessment of nano-sized EPs from blood and provide evidence supporting the direct assessment of EPs in plasma.

Keywords

extracellular particles from blood;extracellular particles from plasma;interferometric light microscopy;dynamic light scattering;

Data

Language: English
Year of publishing:
Typology: 1.08 - Published Scientific Conference Contribution
Organization: UL ZF - University College of Health Studies
UDC: 577
COBISS: 210329603 Link will open in a new window
Views: 32
Downloads: 6
Average score: 0 (0 votes)
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Other data

Type (COBISS): Other
Pages: Str. 71-77
DOI: 10.55295/PSL.11.2024.8
ID: 25242010