Andraž Stožer (Author), Eva Paradiž (Author), Viljem Pohorec (Author), Jurij Dolenšek (Author), Lidija Križančić Bombek (Author), Marko Gosak (Author), Maša Skelin (Author)

Abstract

Pancreatic beta cells secrete insulin in response to stimulation with glucose and other nutrients, and impaired insulin secretion plays a central role in development of diabetes mellitus. Pharmacological management of diabetes includes various antidiabetic drugs, including incretins. The incretin hormones, glucagon-like peptide-1 and gastric inhibitory polypeptide, potentiate glucose-stimulated insulin secretion by binding to G protein-coupled receptors, resulting in stimulation of adenylate cyclase and production of the secondary messenger cAMP, which exerts its intracellular effects through activation of protein kinase A or the guanine nucleotide exchange protein 2A. The molecular mechanisms behind these two downstream signaling arms are still not fully elucidated and involve many steps in the stimulus-secretion coupling cascade, ranging from the proximal regulation of ion channel activity to the central Ca2+ signal and the most distal exocytosis. In addition to modifying intracellular coupling, the effect of cAMP on insulin secretion could also be at least partly explained by the impact on intercellular coupling. In this review, we systematically describe the possible roles of cAMP at these intra- and inter-cellular signaling nodes, keeping in mind the relevance for the whole organism and translation to humans.

Keywords

cAMP;beta cells;stimulus-secretion coupling;intercellular coupling;PKA;Epac2A;

Data

Language: English
Year of publishing:
Typology: 1.02 - Review Article
Organization: UM MF - Faculty of Medicine
Publisher: MDPI
UDC: 612.349.7
COBISS: 70397955 Link will open in a new window
ISSN: 2073-4409
Views: 0
Downloads: 2
Average score: 0 (0 votes)
Metadata: JSON JSON-RDF JSON-LD TURTLE N-TRIPLES XML RDFA MICRODATA DC-XML DC-RDF RDF

Other data

Secondary language: Slovenian
Secondary keywords: beta celice;povezave med dražljaji in izločanjem;medcelične povezave;
Type (COBISS): Scientific work
Pages: str. 1-26
Issue: ǂVol. ǂ10
Chronology: 2021
DOI: 10.3390/cells10071658
ID: 25309259