Andraž Stožer (Avtor), Eva Paradiž (Avtor), Viljem Pohorec (Avtor), Jurij Dolenšek (Avtor), Lidija Križančić Bombek (Avtor), Marko Gosak (Avtor), Maša Skelin (Avtor)

Povzetek

Pancreatic beta cells secrete insulin in response to stimulation with glucose and other nutrients, and impaired insulin secretion plays a central role in development of diabetes mellitus. Pharmacological management of diabetes includes various antidiabetic drugs, including incretins. The incretin hormones, glucagon-like peptide-1 and gastric inhibitory polypeptide, potentiate glucose-stimulated insulin secretion by binding to G protein-coupled receptors, resulting in stimulation of adenylate cyclase and production of the secondary messenger cAMP, which exerts its intracellular effects through activation of protein kinase A or the guanine nucleotide exchange protein 2A. The molecular mechanisms behind these two downstream signaling arms are still not fully elucidated and involve many steps in the stimulus-secretion coupling cascade, ranging from the proximal regulation of ion channel activity to the central Ca2+ signal and the most distal exocytosis. In addition to modifying intracellular coupling, the effect of cAMP on insulin secretion could also be at least partly explained by the impact on intercellular coupling. In this review, we systematically describe the possible roles of cAMP at these intra- and inter-cellular signaling nodes, keeping in mind the relevance for the whole organism and translation to humans.

Ključne besede

cAMP;beta cells;stimulus-secretion coupling;intercellular coupling;PKA;Epac2A;

Podatki

Jezik: Angleški jezik
Leto izida:
Tipologija: 1.02 - Pregledni znanstveni članek
Organizacija: UM MF - Medicinska fakulteta
Založnik: MDPI
UDK: 612.349.7
COBISS: 70397955 Povezava se bo odprla v novem oknu
ISSN: 2073-4409
Št. ogledov: 0
Št. prenosov: 2
Ocena: 0 (0 glasov)
Metapodatki: JSON JSON-RDF JSON-LD TURTLE N-TRIPLES XML RDFA MICRODATA DC-XML DC-RDF RDF

Ostali podatki

Sekundarni jezik: Slovenski jezik
Sekundarne ključne besede: beta celice;povezave med dražljaji in izločanjem;medcelične povezave;
Vrsta dela (COBISS): Znanstveno delo
Strani: str. 1-26
Zvezek: ǂVol. ǂ10
Čas izdaje: 2021
DOI: 10.3390/cells10071658
ID: 25309259