Matjaž Frangež (Author), Noah Emil Glisik (Author), Maša Kaiser (Author), Jaro Vezjak (Author), Matic Žnidaršič (Author), Tanja Zidarič (Author), Tina Maver (Author)

Abstract

Advances in biomedical science have enabled the development of in vitro models that mimic human tissues. Non-invasive real-time monitoring of these models would provide valuable insights without disrupting the cellular environment. This study explores the use of molecularly imprinted polymers (MIPs) for this purpose, focusing on insulin and lactate as biomarkers of cellular metabolism. MIP sensors were created by electropolymerizing pyrrole around insulin or lactate templates on carbon electrodes. The sensors showed high sensitivity and selectivity, with detection ranges of 20.0–70.0 pM for insulin (LOD: 2.41 pM) and 0.5–3.0 mM for lactate. These findings highlight MIPs’ potential for personalized diagnostics and therapy monitoring.

Keywords

biomimetic sensors;molecular imprinting;polypyrrole matrix;insulin;MIP sensor;

Data

Language: English
Year of publishing:
Typology: 1.01 - Original Scientific Article
Organization: UM MF - Faculty of Medicine
Publisher: PAZU
UDC: 60
COBISS: 223684355 Link will open in a new window
ISSN: 2820-364X
Views: 0
Downloads: 0
Average score: 0 (0 votes)
Metadata: JSON JSON-RDF JSON-LD TURTLE N-TRIPLES XML RDFA MICRODATA DC-XML DC-RDF RDF

Other data

Secondary language: Slovenian
Secondary title: Razvoj biomimetičnih senzorjev za določanje funkcionalnosti in vitro celičnih modelov
Secondary keywords: biomimetični senzorji;molekularno vtiskanje;polipirol;inzulin;MIP senzor;
Type (COBISS): Scientific work
Pages: str. 39-57
Volume: ǂVol. ǂ14
Issue: ǂno. ǂ2
Chronology: Dec. 2024
DOI: 10.18690/analipazu.14.2.39-57.2024
ID: 25769836