Matjaž Frangež (Avtor), Noah Emil Glisik (Avtor), Maša Kaiser (Avtor), Jaro Vezjak (Avtor), Matic Žnidaršič (Avtor), Tanja Zidarič (Avtor), Tina Maver (Avtor)

Povzetek

Advances in biomedical science have enabled the development of in vitro models that mimic human tissues. Non-invasive real-time monitoring of these models would provide valuable insights without disrupting the cellular environment. This study explores the use of molecularly imprinted polymers (MIPs) for this purpose, focusing on insulin and lactate as biomarkers of cellular metabolism. MIP sensors were created by electropolymerizing pyrrole around insulin or lactate templates on carbon electrodes. The sensors showed high sensitivity and selectivity, with detection ranges of 20.0–70.0 pM for insulin (LOD: 2.41 pM) and 0.5–3.0 mM for lactate. These findings highlight MIPs’ potential for personalized diagnostics and therapy monitoring.

Ključne besede

biomimetic sensors;molecular imprinting;polypyrrole matrix;insulin;MIP sensor;

Podatki

Jezik: Angleški jezik
Leto izida:
Tipologija: 1.01 - Izvirni znanstveni članek
Organizacija: UM MF - Medicinska fakulteta
Založnik: PAZU
UDK: 60
COBISS: 223684355 Povezava se bo odprla v novem oknu
ISSN: 2820-364X
Št. ogledov: 0
Št. prenosov: 0
Ocena: 0 (0 glasov)
Metapodatki: JSON JSON-RDF JSON-LD TURTLE N-TRIPLES XML RDFA MICRODATA DC-XML DC-RDF RDF

Ostali podatki

Sekundarni jezik: Slovenski jezik
Sekundarni naslov: Razvoj biomimetičnih senzorjev za določanje funkcionalnosti in vitro celičnih modelov
Sekundarne ključne besede: biomimetični senzorji;molekularno vtiskanje;polipirol;inzulin;MIP senzor;
Vrsta dela (COBISS): Znanstveno delo
Strani: str. 39-57
Letnik: ǂVol. ǂ14
Zvezek: ǂno. ǂ2
Čas izdaje: Dec. 2024
DOI: 10.18690/analipazu.14.2.39-57.2024
ID: 25769836