Changhan Lee (Author), Jens Klockgether (Author), Sebastian Fischer (Author), Janja Trček (Author), Burkhard Tümmler (Author), Ute Römling (Author)

Abstract

The environmental species Pseudomonas aeruginosa thrives in a variety of habitats. Within the epidemic population structure of P. aeruginosa, occassionally highly successful clones that are equally capable to succeed in the environment and the human host arise. Framed by a highly conserved core genome, individual members of successful clones are characterized by a high variability in their accessory genome. The abundance of successful clones might be funded in specific features of the core genome or, although not mutually exclusive, in the variability of the accessory genome. In clone C, one of the most predominant clones, the plasmid pKLC102 and the PACGI-1 genomic island are two ubiquitous accessory genetic elements. The conserved transmissible locus of protein quality control (TLPQC) at the border of PACGI-1 is a unique horizontally transferred compository element, which codes predominantly for stress-related cargo gene products such as involved in protein homeostasis. As a hallmark, most TLPQC xenologues possess a core genome equivalent. With elevated temperature tolerance as a characteristic of clone C strains, the unique P. aeruginosa and clone C specific disaggregase ClpG is a major contributor to tolerance. As other successful clones, such as PA14, do not encode the TLPQC locus, ubiquitous denominators of success, if existing, need to be identified.

Keywords

disaggregase;FtsH;genomic island;protein homeostasis;whole genome sequencing;

Data

Language: English
Year of publishing:
Typology: 1.02 - Review Article
Organization: UM FNM - Faculty of Natural Sciences and Mathematics
Publisher: Blackwell Publishing
UDC: 579
COBISS: 31111427 Link will open in a new window
ISSN: 0168-6445
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Other data

Secondary language: Slovenian
Secondary keywords: dezagregacija;genomski otok;proteinska homeostaza;elektroforeza v pulznem polju;sekvenciranje celotnega genoma;
Type (COBISS): Scientific work
Pages: str. 740-762
Volume: ǂVol. ǂ44
Issue: ǂno. ǂ6
Chronology: 2020
DOI: 10.1093/femsre/fuaa029
ID: 25795143