Functionalized micellar membranes from medicinal mushrooms as promising self-growing bioscaffolds

Nika Kučuk (Author), Mateja Primožič (Author), Željko Knez (Author), Maja Leitgeb (Author)

Abstract

Micellar or mycelial membranes from medicinal mushrooms are self-growing fibrous polymeric biocomposites that are biocompatible, biodegradable, cost-effective, and environmentally friendly. In this study, the cultivation process for the medicinal mushrooms Ganoderma lucidum and Pleurotus ostreatus has been optimized via submerged cultivation to maximize growth and promote the formation of micellar membranes with high water-absorption capacity. Optimal growth conditions were achieved at an alkaline pH in a medium containing malt extract for G. lucidum, while for P. ostreatus, these were in a glucose-enriched medium. The hydrophilic underside of the micellar membranes led to a high-water uptake capacity. These membranes exhibited a broad spectrum of functional groups, thermal stability with decomposition temperatures above 260 °C, and a fibrous and porous structure. The micellar membranes from both mushrooms were additionally functionalized with mango peel extract (MPE), resulting in a uniform and gradual release profile, which is an important novelty. They also showed successful antimicrobial activity against Escherichia coli and Staphylococcus aureus growth. MPE-functionalized micellar membranes are, therefore, innovative biocomposites suitable for various biomedical applications. As they mimic the extracellular matrix of the skin, they are a promising material for tissue engineering, wound healing, and advanced skin materials applications.

Keywords

medicinske gobe;micelarne membrane;funkcionlizacija;antibakterijsko;ostrigar;medicinal mushrooms;Ganoderma lucidum;Pleurotus ostreatus;

Data

Language:	English
Year of publishing:	2025
Typology:	1.01 - Original Scientific Article
Organization:	UM FKKT - Faculty of Chemistry and Chemical Engineering
Publisher:	MDPI
UDC:	66.02
COBISS:	247369475
ISSN:	2073-4360
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Downloads:	0
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Other data

Secondary language:	Slovenian
Secondary keywords:	medicinske gobe;micelarne membrane;funkcionlizacija;antibakterijsko;ostrigar;
Type (COBISS):	Article
Pages:	37 str.
Volume:	ǂVol. ǂ17
Issue:	ǂiss. ǂ17, [article no.] 2334
Chronology:	2025
DOI:	10.3390/polym17172334
ID:	27245212