Sergej Tomić (Author), Rebeka Rudolf (Author), Mihael Brunčko (Author), Ivan Anžel (Author), V. Savić (Author), Miodrag Čolić (Author)

Abstract

Ni-Ti Shape Memory Alloys (SMAs) have attracted considerable attention as biomaterials for medical devices. However, the biocompatibility of Ni-Ti SMAs is often unsatisfactory due to their poor surface structure. Here we prepared Rapidly Solidifi ed (RS) Ni-Ti SMA ribbons by melt-spinning and their surface was characterised by Augerelectron spectroscopy, X-ray photoelectron spectrometry and scanning electron microscopy. The biocompatibility of the produced ribbons and their immunomodulatory properties were studied on human monocyte-derived dendritic cells (MoDCs). We showed that melt-spinning of Ni-Ti SMAs can form a thin homogenous oxide layer, which improves their corrosion resistance and subsequent toxicity to MoDCs. Ni-Ti RS ribbons stimulated the maturation of MoDCs, as detected by changes in the cellsć morphology and increased expression of HLA-DR, CD86, CD40 and CD83 molecules. However, Ni-Ti RS ribbons enhanced the tolerogenic properties of immature MoDCs, which produced higher levels of IL-10 and IL-27, driving the differentiation of IL-10- and TGF-â-producing CD4+T cells. On the other hand, in the presence of lipopolysaccharide, an important pro-infl ammatory biomolecule, Ni-Ti RS ribbons enhanced the allostimulatory and Th1 polarising capacity of MoDCs, whereas the production of Th2 and Th17 cytokines was down-regulated. In conclusion, Ni- Ti RS ribbons possess substantial immunomodulatory properties on MoDCs. These fi ndings might be clinically relevant, because implanted Ni-Ti SMA devices can induce both desired and adverse effects on the immune system, depending on the microenvironmental stimuli.

Keywords

nickel-titanium alloy;biocompatibility;cytokines;immunomodulation;monocyte-derived dendritic cells;

Data

Language: English
Year of publishing:
Typology: 1.01 - Original Scientific Article
Organization: UM FS - Faculty of Mechanical Engineering
UDC: 669:61
COBISS: 15705366 Link will open in a new window
ISSN: 1473-2262
Views: 1651
Downloads: 328
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Other data

Secondary language: Slovenian
Secondary keywords: nikelj-titanova zlitina;biokompatibilnost;citokini;imunomodulacija;monocitne dendritične celice;
URN: URN:SI:UM:
Type (COBISS): Scientific work
Pages: str. 58-80
Issue: ǂVol. ǂ23
Chronology: Jan.-June 2012
DOI: 10.22203/eCM.v023a05
ID: 8718484