Preučevanje fizikalno-kemijskih lastnosti učinkovin s termoanaliznimi tehnikami

diplomsko delo univerzitetnega študijskega programa I. stopnje

Elma Mamić (Author), Irena Ban (Mentor), Matjaž Kristl (Co-mentor)

Abstract

Z metodami DSC in TGA smo preučevali termične lastnosti paracetamola (PCM) in polietilen glikola (PEG) različnih molskih mas ter njihovih različnih mešanic. Spremljali smo spremembe talilnega pika PCM enostavnih fizikalnih mešanic glede na čisto učinkovino, pripravljenih z mehanskim mešanjem v ahatni tarilnici in pripravljenih na način, da smo stalili mešanice na vodni kopeli, ohladili in posneli na DSC. Primerjali smo vpliv različnih tehnik priprave mešanic na obliko DSC krivulje. Prav tako smo preučevali vpliv hitrosti gretja pri DSC meritvah na temperaturo talilnih pikov PEG. Meritve so bile narejene v atmosferi zraka. Ugotovili smo, da so interakcije med učinkovino in PEG odvisne od sestave mešanic, molske mase PEG in načina priprave mešanic. Prav tako smo spremljali kristaličnost PCM po prvem in drugem segrevanju mešanic.

Keywords

termična analiza;diferenčna dinamična kalorimetrija;DSC;termogravimetrična analiza;TGA;polietilen glikol;PEG;paracetamol;PCM;

Data

Language:	Slovenian
Year of publishing:	2015
Typology:	2.11 - Undergraduate Thesis
Organization:	UM FKKT - Faculty of Chemistry and Chemical Engineering
Publisher:	[E. Mamić]
UDC:	543.572/.573(043.2)
COBISS:	19124246
Views:	2005
Downloads:	185
Average score:	0 (0 votes)
Metadata:

Other data

Secondary language:	English
Secondary title:	STUDYING PHYSICAL AND CHEMICAL PROPERTIES OF ACTIVE SUBSTANCES WITH THERMO ANALYSING TECHNIQUES
Secondary abstract:	We have studied thermal properties of paracetamol and polyethylene glycol (PEG) of different molecular masses and various mixtures of them by DSC and TGA analysis. We were observing changes in the PCM melting curve of simple physical mixtures according to the pure active substance. We prepared the mixtures in the agate mortar and then we melted the mixtures on a water bath. The mixtures were cooled down in air and then analysed with DSC. We compared the influence of two different techniques of mixture preparation on the shape of DSC curve. We have also studied the influence of heating rate on the DSC curves and the melting peaks of PEG. Measurements were made in an air atmosphere. We have found out that the interactions between the active ingredient and the PEG depend on the composition of the mixtures, the molecular weight of the PEG and the method of mixing. We have also observed the crystalline structure of PCM after the first and after the second heating of the mixtures.
Secondary keywords:	thermal analysis;differential scanning calorimetry;DSC;thermogravimetric analysis;TGA;polyethylene glycol;PEG;paracetamol;PCM;
URN:	URN:SI:UM:
Type (COBISS):	Bachelor thesis/paper
Thesis comment:	Univ. v Mariboru, Fak. za kemijo in kemijsko tehnologijo
Pages:	VIII, 36 str.
ID:	8901649