Roman Kranvogl (Author), Jure Knez (Author), Alen Miuc (Author), Ernest Vončina (Author), Darinka Brodnjak-Vončina (Author), Veljko Vlaisavljević (Author)

Abstract

A GC-MS method was successfully applied to measure simultaneously the concentrations of endocrine disrupting compounds (5 dialkyl phthalates, 9 phthalate monoesters, 3 alkylphenols and bisphenol A) in 136 male urine samples. In the present study the method was validated and concentrations of EDCs were determined. The results were compared with results from other studies. Correlations between endocrine disrupting compounds and also correlations of endocrine disrupting compounds with two semen quality parameters are presented and evaluated. Significant positive correlations were found between almost all the endocrine disrupting compounds. The parameter sum of DEHP (SUM DEHP) was positively correlated to all the endocrine disrupting compounds but negatively to two semen quality parameters. Negative correlations between the endocrine disrupting compounds and the semen quality parameters could indicate that endocrine disrupting compounds could cause reproductive problems by decreasing the semen count and quality. This research will have helped to evaluate human exposure to endocrine disrupting compounds.

Keywords

endocrine disrupting compounds;fertility;phthalates;bisphenol A;alkylphenols;human urine;

Data

Language: English
Year of publishing:
Typology: 1.01 - Original Scientific Article
Organization: UM FKKT - Faculty of Chemistry and Chemical Engineering
UDC: 543.21:663.2
COBISS: 17710102 Link will open in a new window
ISSN: 1318-0207
Views: 1239
Downloads: 98
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Other data

Secondary language: Slovenian
Secondary abstract: S plinsko kromatografijo in masno spektrometrijo smo simultano določali koncentracije endokrinih motilcev (5 dialkil ftalatov, 9 monoalkil ftalatov, 3 alkilfenole in bisfenol A) v 136 vzorcih moških urinov. Rezultate smo primerjali z ostalimi študijami. Ovrednotili smo korelacije med endokrinimi motilci in korelacije med endokrinimi motilci ter parametri semena. Signifikantne pozitivne korelacije obstajajo med skoraj vsemi endokrinimi motilci. Parameter vsote DEHP (SUM DEHP) pozitivno korelira z vsemi endokrinimi motilci in negativno s paramateri kvalitete semena. Negativne korelacije med endokrinimi motilci ter parametri kvalitete semena nakazujejo, da lahko povzročajo probleme s plodnostjo z zmanjšanjem koncentracije in gibljivosti semena. Raziskava bo pripomogla k ovrednotenju izpostavljenosti ljudi vplivom endokrinih motilcev.
Secondary keywords: analizna kemija;endokrini motilci;ftalati;urin;plinska kromatografija;kemijska analiza;
URN: URN:NBN:SI
Type (COBISS): Scientific work
Pages: str. 110-120
Volume: ǂVol. ǂ61
Issue: ǂno. ǂ1
Chronology: 2014
ID: 9101641