Synthesis comparison and characterization of chitosan-coated magnetic nanoparticles prepared with different methods

Gordana Hojnik Podrepšek (Author), Željko Knez (Author), Maja Leitgeb (Author)

Abstract

In this study, magnetic maghemite nanoparticles were prepared with the coprecipitation method, due to its simplicity and productivity. Thereafter, chitosan-coated magnetic nanoparticles were synthesized with three different methods, the micro-emulsion process, the suspension cross-linking technique and the covalent binding. Subsequently, a comparison of the used methods was done using various analyses such as Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), thermogravimetry (TGA), differential scanning calorimetry (DSC), vibrating-sample magnetometry (VSM) and dynamic light scattering (DLS). The characterization results from Fourier transform infrared (FTIR) spectroscopy and thermogravimetric analysis (TGA) indicated a successful binding of chitosan on the magnetic nanoparticles. SEM pictures showed that spherical structured particles with an increased particle size were obtained as the chitosan layer around the particles was increased. Considering that the magnetic-separation technique has the advantages of rapidity, high efficiency, cost-effectiveness and lack of negative effect on the biological activity, these carriers may be applied in enzyme immobilization.

Keywords

magnetic nanoparticles;chitosan;surface functionalization;

Data

Language:	English
Year of publishing:	2014
Typology:	1.01 - Original Scientific Article
Organization:	UM FKKT - Faculty of Chemistry and Chemical Engineering
Publisher:	Inštitut za kovinske materiale in tehnologije Ljubljana
UDC:	66.02
COBISS:	18207766
ISSN:	1580-2949
Parent publication:	Materiali in tehnologije
Views:	1044
Downloads:	85
Average score:	0 (0 votes)
Metadata:

Other data

Secondary language:	Slovenian
Secondary title:	Primerjava postopkov in karakterizacija magnetnih nanodelcev, prevlečenih s hitozanom
Secondary abstract:	V prispevku je opisana enostavna priprava magnetnih nanodelcev, prevlečenih s hitozanom. Postopek je potekal v dveh stopnjah. V prvi smo sintetizirali magnetne nanodelce s koprecipitacijo železovih ionov. V drugi smo nanodelce prevlekli s hitozanom, da bi preprečili aglomeracijo, z uporabo treh različnih postopkov: z metodo mikroemulzije, metodo zamreženja in s kovalentno vezavo. Karakterizacija tako pripravljenih nanodelcev je bila izvedena s Fourierjevo transformacijsko infrardečo spektroskopijo (FTIR), z vrstično elektronsko mikroskopijo (SEM), s termogravimetrično analizo (TGA), z diferencialno dinamično kalorimetrijo (DSC), z analizo vibracijskega magnetometra (VSM) in dinamičnim sipanjem laserske svetlobe (DLS). Rezultati analiz FTIR in TGA so potrdili vezavo hitozana na magnetne nanodelce, medtem ko je bila oblika in debelina sloja hitozana določena s SEM-analizo. Ker ima tehnika magnetnih nanodelcev veliko prednosti pri ločevanju, cenejši proizvodnji in nima negativnih učinkov na biološko aktivnost, se lahko potencialno uporablja pri encimski imobilizaciji.
Secondary keywords:	magnetni nanodelci;hitozan;površinska funkcionalizacija;
URN:	URN:NBN:SI
Type (COBISS):	Scientific work
Pages:	str. 689-692
Volume:	ǂLetn. ǂ48
Issue:	ǂšt. ǂ5
Chronology:	sep.-okt. 2014
ID:	9593826