Daniela Cesselli (Author), Aneta Aleksova (Author), Elisa Mazzega (Author), Angela Caragnano (Author), Antonio Paolo Beltrami (Author)

Abstract

A side effect of the medical improvements of the last centuries is the progressive aging of the world population, which is estimated to reach the impressive number of 2 billion people with more than 65 years by 2050. As a consequence, age-related diseases, such as heart failure, will affect more and more patients in the next years. To understand the biological bases of these diseases will be a crucial task in order to find better treatments, and possibly slow age-related morbidity and mortality. Cardiac stem cells have been at the center of a heated debate and their potential involvement in cardiac homeostasis has been questioned. In this review, we summarize evidence obtained by independent groups, on different animal models and humans, that strongly support the important role played by immature, cardiac resident cells in the cardioprotection against heart failure.

Keywords

aging;heart failure;cardiomyocyte turnover;stem cells;cell senescence;cKit;Sca1;cardiospheres;

Data

Language: English
Year of publishing:
Typology: 1.02 - Review Article
Organization: UNG - University of Nova Gorica
UDC: 615
COBISS: 4759291 Link will open in a new window
ISSN: 1043-6618
Views: 3687
Downloads: 0
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Other data

URN: URN:SI:UNG
Type (COBISS): Not categorized
Pages: str. 26-32
Issue: ǂVol. ǂ127
Chronology: 2018
DOI: 10.1016/j.phrs.2017.01.013
ID: 9595103