Daniela Cesselli (Avtor), Aneta Aleksova (Avtor), Elisa Mazzega (Avtor), Angela Caragnano (Avtor), Antonio Paolo Beltrami (Avtor)

Povzetek

A side effect of the medical improvements of the last centuries is the progressive aging of the world population, which is estimated to reach the impressive number of 2 billion people with more than 65 years by 2050. As a consequence, age-related diseases, such as heart failure, will affect more and more patients in the next years. To understand the biological bases of these diseases will be a crucial task in order to find better treatments, and possibly slow age-related morbidity and mortality. Cardiac stem cells have been at the center of a heated debate and their potential involvement in cardiac homeostasis has been questioned. In this review, we summarize evidence obtained by independent groups, on different animal models and humans, that strongly support the important role played by immature, cardiac resident cells in the cardioprotection against heart failure.

Ključne besede

aging;heart failure;cardiomyocyte turnover;stem cells;cell senescence;cKit;Sca1;cardiospheres;

Podatki

Jezik: Angleški jezik
Leto izida:
Tipologija: 1.02 - Pregledni znanstveni članek
Organizacija: UNG - Univerza v Novi Gorici
UDK: 615
COBISS: 4759291 Povezava se bo odprla v novem oknu
ISSN: 1043-6618
Št. ogledov: 3687
Št. prenosov: 0
Ocena: 0 (0 glasov)
Metapodatki: JSON JSON-RDF JSON-LD TURTLE N-TRIPLES XML RDFA MICRODATA DC-XML DC-RDF RDF

Ostali podatki

URN: URN:SI:UNG
Vrsta dela (COBISS): Delo ni kategorizirano
Strani: str. 26-32
Zvezek: ǂVol. ǂ127
Čas izdaje: 2018
DOI: 10.1016/j.phrs.2017.01.013
ID: 9595103