diplomsko delo
Tjaša Kocjančič (Author), Mitja Kolar (Mentor), Darinka Brodnjak-Vončina (Co-mentor), Marija Meleh (Co-mentor)

Abstract

Namen diplomske naloge je bil s pomočjo mikro plinske kromatografije (µGC) razviti enostavno in zanesljivo analizno metodo za določevanje kisika in vode v farmacevtski embalaži ter jo ustrezno ovrednotiti. Najprej smo s pomočjo plinskih standardnih mešanic razvili metodo na µGC instrumentu ter optimizirali analizne pogoje (temperaturo vhoda, injektorja in kolone, čas črpanja vzorca, čas injiciranja in čas analize ter tlak kolone). Kot nosilni plin smo pri vseh analizah uporabili argon. Ker µGC instrument ni imel posebnega nastavka za injiciranje atmosfere iz farmacevtske embalaže, smo ga modificirali in opremili z injekcijsko iglo, ki smo jo dodatno zatesnili in z navojem privili na injektor. Za čim boljšo ponovljivost injiciranja pri določanju atmosfere v žepkih smo poskrbeli tako, da smo na žepke nanesli silikon (Tekasil-Neutral Profi), in ga sušili pri sobni temperaturi 72 ur. S pomočjo modificirane igle smo nato prodrli v notranjost žepka, ne da bi pri tem kontaminirali vsebino vzorca z zunanjo atmosfero. Metodo smo uspešno uporabili na več vzorcih ter jo primerjali s plinsko kromatografijo v povezavi z masno spektrometrijo.

Keywords

plinska kromatografija;toplotna prevodnost;farmacevtska embalaža;

Data

Language: Slovenian
Year of publishing:
Source: Maribor
Typology: 2.11 - Undergraduate Thesis
Organization: UM FKKT - Faculty of Chemistry and Chemical Engineering
Publisher: [T. Kocjančič]
UDC: 543.544.3:661.12(043.2)
COBISS: 13926934 Link will open in a new window
Views: 2558
Downloads: 356
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Other data

Secondary language: English
Secondary title: Determination of atmosphere in pharmaceutical packages using micro gas chromatography
Secondary abstract: The aim of the diploma thesis is to develop a simple and reliable analytical method for determination of oxygen and water content in pharmaceutical packaging blisters using micro gas chromatography (µGC). In the first place conditions of analytical procedure were optimised, namely inlet temperature, injector temperature, column temperature, sampling time, injection time, run time and column pressure. For this purpose standard gas mixtures were used. Argon was used as the carrier gas in the GC analysis. The µGC instrument was not equipped with an attachment for the injection of atmosphere from pharmaceutical packaging blisters. Consequently, the attachment had to be made especially from a modified hypodermic needle that further required sealing with a screw mount to the injector. For obtaining best reproducibility of injections for determination of atmosphere in pharmaceutical packages we applied silicon (Tekasil-Neutral Profi), which was then permitted to dry for 72 hours, so that it became completely dry. Using the modified hypodermic needle it was possible to penetrate into the interior of the blister. This made possible for the atmosphere in the blister to be sampled without possible contamination from the external atmosphere. The method was successfully applied to a number of samples and was compared with the existing method using gas chromatography coupled with mass spectrometry.
Secondary keywords: gas chromatography;micro GC;thermal conductivity;TCD detector;pharmaceutical blister packing;
URN: URN:SI:UM:
Type (COBISS): Undergraduate thesis
Thesis comment: Univ. v Mariboru, Fak. za kemijo in kemijsko tehnologijo
Pages: XIV, 69 f.
Keywords (UDC): mathematics;natural sciences;naravoslovne vede;matematika;chemistry;crystallography;mineralogy;kemija;analytical chemistry;analizna kemija;physicochemical methods of analysis (other than optical methods);applied sciences;medicine;technology;uporabne znanosti;medicina;tehnika;chemical technology;chemical and related industries;kemijska tehnologija;kemijske in sorodne industrije;chemicals;kemikalije;kemijski produkti;special chemical industries;specialne kemijske industrije;
ID: 987752