ǂan ǂobservational study
Maximilian J Hochmair (Avtor),
Alessandro Morabito (Avtor),
Desiree Hao (Avtor),
Cheng-Ta Yang (Avtor),
Ross A Soo (Avtor),
James C-H Yang (Avtor),
Rasim Gucalp (Avtor),
Balazs Halmos (Avtor),
Lara Wang (Avtor),
Amanda Golembesky (Avtor),
Angela Märten (Avtor),
Tanja Čufer (Avtor)
Povzetek
Aim: To assess outcomes in patients with EGFR mutation-positive (Del19, L858R) non-small-cell lung cancer receiving sequential afatinib and osimertinib in a real-world clinical setting. Materials & methods: In this retrospective, observational, multicenter study, patients (n = 204) had T790M-positive disease following first-line afatinib and started osimertinib treatment [>/=]10 months prior to data entry. Primary outcome was time on treatment. Results: Overall median time on treatment was 27.6 months (90% CI: 25.9-31.3), 30.3 months (90% CI: 27.6-44.5) in Del19-positive patients and 46.7 months (90% CI: 26.8-not reached) in Asians. The 2-year overall survival was 78.9%. Conclusion: In real-world clinical practice, sequential afatinib and osimertinib facilitates prolonged, chemotherapy-free treatment in patients with T790M acquired resistance, and is a potentially attractive strategy, especially for Del19-positive tumors.
Ključne besede
non-small-cell lung cancer;afatinib;osimertinib;epidermal growth factor receptor;EGFR;observational study;
Podatki
Jezik: |
Angleški jezik |
Leto izida: |
2018 |
Tipologija: |
1.01 - Izvirni znanstveni članek |
Založnik: |
Future Medicine Ltd |
UDK: |
616-006 |
COBISS: |
2048432753
|
ISSN: |
1744-8301 |
Št. ogledov: |
918 |
Št. prenosov: |
519 |
Ocena: |
0 (0 glasov) |
Metapodatki: |
|
Ostali podatki
Sekundarne ključne besede: |
nedrobnocelični pljučni rak;afatinib;osimertinib;receptor za epidermalni rastni dejavnik;EGFR;opazovalna raziskava;Lung neoplasms;Therapy;Pljučne novotvorbe;Terapija; |
Komentar vira: |
Soavtorji: Alessandro Morabito, Desiree Hao, Cheng-Ta Yang, Ross A Soo, James C-H Yang, Rasim Gucalp, Balazs Halmos, Lara Wang, Amanda Golembesky, Angela Märten & Tanja Cufer;
Nasl. z nasl. zaslona;
Opis vira z dne 9. 1. 2019;
|
Strani: |
str. 2861-2874 |
Letnik: |
ǂVol. ǂ14 |
Zvezek: |
ǂno. ǂ27 |
Čas izdaje: |
Nov. 2018 |
DOI: |
10.2217/fon-2018-0711 |
ID: |
12143216 |