ǂan ǂobservational study
Maximilian J Hochmair (Avtor), Alessandro Morabito (Avtor), Desiree Hao (Avtor), Cheng-Ta Yang (Avtor), Ross A Soo (Avtor), James C-H Yang (Avtor), Rasim Gucalp (Avtor), Balazs Halmos (Avtor), Lara Wang (Avtor), Amanda Golembesky (Avtor), Angela Märten (Avtor), Tanja Čufer (Avtor)

Povzetek

Aim: To assess outcomes in patients with EGFR mutation-positive (Del19, L858R) non-small-cell lung cancer receiving sequential afatinib and osimertinib in a real-world clinical setting. Materials & methods: In this retrospective, observational, multicenter study, patients (n = 204) had T790M-positive disease following first-line afatinib and started osimertinib treatment [>/=]10 months prior to data entry. Primary outcome was time on treatment. Results: Overall median time on treatment was 27.6 months (90% CI: 25.9-31.3), 30.3 months (90% CI: 27.6-44.5) in Del19-positive patients and 46.7 months (90% CI: 26.8-not reached) in Asians. The 2-year overall survival was 78.9%. Conclusion: In real-world clinical practice, sequential afatinib and osimertinib facilitates prolonged, chemotherapy-free treatment in patients with T790M acquired resistance, and is a potentially attractive strategy, especially for Del19-positive tumors.

Ključne besede

non-small-cell lung cancer;afatinib;osimertinib;epidermal growth factor receptor;EGFR;observational study;

Podatki

Jezik: Angleški jezik
Leto izida:
Tipologija: 1.01 - Izvirni znanstveni članek
Založnik: Future Medicine Ltd
UDK: 616-006
COBISS: 2048432753 Povezava se bo odprla v novem oknu
ISSN: 1744-8301
Št. ogledov: 918
Št. prenosov: 519
Ocena: 0 (0 glasov)
Metapodatki: JSON JSON-RDF JSON-LD TURTLE N-TRIPLES XML RDFA MICRODATA DC-XML DC-RDF RDF

Ostali podatki

Sekundarne ključne besede: nedrobnocelični pljučni rak;afatinib;osimertinib;receptor za epidermalni rastni dejavnik;EGFR;opazovalna raziskava;Lung neoplasms;Therapy;Pljučne novotvorbe;Terapija;
Komentar vira: Soavtorji: Alessandro Morabito, Desiree Hao, Cheng-Ta Yang, Ross A Soo, James C-H Yang, Rasim Gucalp, Balazs Halmos, Lara Wang, Amanda Golembesky, Angela Märten & Tanja Cufer; Nasl. z nasl. zaslona; Opis vira z dne 9. 1. 2019;
Strani: str. 2861-2874
Letnik: ǂVol. ǂ14
Zvezek: ǂno. ǂ27
Čas izdaje: Nov. 2018
DOI: 10.2217/fon-2018-0711
ID: 12143216