Assessing spectral imaging of the human finger for detection of arthritis

Rok Dolenec (Avtor), Elmar Laistler (Avtor), Matija Milanič (Avtor)

Povzetek

Rheumatoid arthritis causes changes in the optical properties of tissues in the joints, which could be detected using spectral imaging. This has the potential for development of low cost, non-contact method for early detection of the disease. In this work, hyperspectral imaging system was used to obtain 24 images of proximal interphalangeal joints of 12 healthy volunteers. A large inter-subject variability was observed, but still an increase in transmittance in the spectral range of 600 nm – 950 nm could be associated to the joint in all images. The results of experiments were compared to detailed simulations of light propagation trough tissue. For the simulations, voxelized 3D models of unaffected and inflamed human joints with realistic tissue distributions were constructed from an in-vivo MRI scan of a healthy human finger. The simulated model of healthy finger successfully reproduced the experimental data, while the affected models indicated that the inflammation introduces detectable differences in the spectral and spatial features. The results were used to guide the design of a dedicated imaging system for detection of rheumatoid arthritis, that will be used in an upcoming clinical study.

Ključne besede

medicinska fizika;medicinsko slikanje;artritis;optika;medical physics;medical imaging;arthritis;optics;

Podatki

Jezik:	Angleški jezik
Leto izida:	2019
Tipologija:	1.01 - Izvirni znanstveni članek
Organizacija:	UL FMF - Fakulteta za matematiko in fiziko
UDK:	616-073
COBISS:	3386980
ISSN:	2156-7085
Št. ogledov:	568
Št. prenosov:	154
Ocena:	0 (0 glasov)
Metapodatki:

Ostali podatki

Sekundarni jezik:	Slovenski jezik
Sekundarne ključne besede:	medicinska fizika;medicinsko slikanje;artritis;optika;
Vrsta dela (COBISS):	Članek v reviji
Strani:	str. 6555-6568
Letnik:	ǂVol. ǂ10
Zvezek:	ǂno. ǂ12
Čas izdaje:	2019
DOI:	10.1364/BOE.10.006555
ID:	13157075