Pouline M. van Oort (Avtor), Tamara M. E. Nijsen (Avtor), I. R. White (Avtor), Hugo Knobel (Avtor), Timothy Felton (Avtor), Nicholas J. W. Rattray (Avtor), Oluwasola Lawal (Avtor), Murtaza Bulut (Avtor), Waqar Ahmed (Avtor), Antonio Artigas (Avtor)

Povzetek

Patients suspected of ventilator-associated lower respiratory tract infections (VA-LRTIs) commonly receive broad-spectrum antimicrobial therapy unnecessarily. We tested whether exhaled breath analysis can discriminate between patients suspected of VA-LRTI with confirmed infection, from patients with negative cultures. Breath from 108 patients suspected of VA-LRTI was analysed by gas chromatography-mass spectrometry. The breath test had a sensitivity of 98% at a specificity of 49%, confirmed with a second analytical method. The breath test had a negative predictive value of 96% and excluded pneumonia in half of the patients with negative cultures. Trial registration number: UKCRN ID number 19086, registered May 2015.

Ključne besede

ventilator-associated pneumonia;breath analysis;volatile organic compounds;metabolomics;intensive care;hospital acquired infections;

Podatki

Jezik: Angleški jezik
Leto izida:
Tipologija: 1.03 - Kratki znanstveni prispevek
Organizacija: UNG - Univerza v Novi Gorici
UDK: 616.2
COBISS: 75487235 Povezava se bo odprla v novem oknu
ISSN: 0040-6376
Št. ogledov: 1354
Št. prenosov: 0
Ocena: 0 (0 glasov)
Metapodatki: JSON JSON-RDF JSON-LD TURTLE N-TRIPLES XML RDFA MICRODATA DC-XML DC-RDF RDF

Ostali podatki

URN: URN:SI:UNG
Strani: str. 1-3
Letnik: ǂVol. ǂ
Zvezek: ǂiss. ǂ
Čas izdaje: 2021
DOI: 10.1136/thoraxjnl-2021-217362
ID: 13324803
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