Tamás Pivarcsik (Avtor), Gábor Tóth (Avtor), Nikoletta Szemerédi (Avtor), Anita Bogdanov (Avtor), Gabriella Spengler (Avtor), Jakob Kljun (Avtor), Jerneja Kladnik (Avtor), Iztok Turel (Avtor), Éva A. Enyedy (Avtor)

Povzetek

In this work, the various biological activities of eight organoruthenium(II) complexes were evaluated to reveal correlations with their stability and reactivity in aqueous media. Complexes with general formula [Ru(η$^6$-p-cymene)(X,Y)(Z)] were prepared, where (X,Y) represents either an O,Oligand (β-diketone), N,O-ligand (8-hydroxyquinoline) or O,S-pyrithione-type ligands (pyrithione = 1-hydroxypyridine-2(1H)-thione) with Cl$^−$ or 1,3,5-triaza-7-phosphaadamantane (PTA) as a co-ligand (Z). The tested complexes inhibit the chlamydial growth on HeLa cells, and one of the complexes inhibits the growth of the human herpes simplex virus-2. The chlorido complexes with N,O- and O,S-ligands displayed strong antibacterial activity on Gram-positive strains including the resistant S. aureus (MRSA) and were cytotoxic in adenocarcinoma cell lines. Effect of the structural variation on the biological properties and solution stability was clearly revealed. The decreased bioactivity of the β-diketone complexes can be related to their lower stability in solution. In contrast, the O,Spyrithione-type complexes are highly stable in solution and the complexation prevents the oxidation of the O,S-ligands. Comparing the binding of PTA and the chlorido co-ligands, it can be concluded that PTA is generally more strongly coordinated to ruthenium, which at the same time decreased the reactivity of complexes with human serum albumin or 1-methylimidazole as well as diminished their bioactivity.

Ključne besede

rutenij;organorutenijevi kompleksi;ligandi;kemijske lastnosti;biološka aktivnost;

Podatki

Jezik: Angleški jezik
Leto izida:
Tipologija: 1.01 - Izvirni znanstveni članek
Organizacija: UL FKKT - Fakulteta za kemijo in kemijsko tehnologijo
UDK: 546.96:547.8
COBISS: 65179139 Povezava se bo odprla v novem oknu
ISSN: 1424-8247
Št. ogledov: 112
Št. prenosov: 44
Ocena: 0 (0 glasov)
Metapodatki: JSON JSON-RDF JSON-LD TURTLE N-TRIPLES XML RDFA MICRODATA DC-XML DC-RDF RDF

Ostali podatki

Sekundarni jezik: Slovenski jezik
Sekundarne ključne besede: rutenij;organorutenijevi kompleksi;ligandi;kemijske lastnosti;biološka aktivnost;
Vrsta dela (COBISS): Članek v reviji
Strani: str. 1-24
Letnik: ǂVol. ǂ14
Zvezek: ǂiss. ǂ6
Čas izdaje: Jun. 2021
DOI: 10.3390/ph14060518
ID: 14751396