Špela Gruden (Avtor), Nataša Poklar Ulrih (Avtor)

Povzetek

Lactoferrins are an iron-binding glycoprotein that have important protective roles in the mammalian body through their numerous functions, which include antimicrobial, antitumor, anti-inflammatory, immunomodulatory, and antioxidant activities. Among these, their antimicrobial activity has been the most studied, although the mechanism behind antimicrobial activities remains to be elucidated. Thirty years ago, the first lactoferrin-derived peptide was isolated and showed higher antimicrobial activity than the native lactoferrin lactoferricin. Since then, numerous studies have investigated the antimicrobial potencies of lactoferrins, lactoferricins, and other lactoferrin-derived peptides to better understand their antimicrobial activities at the molecular level. This review defines the current antibacterial, antiviral, antifungal, and antiparasitic activities of lactoferrins, lactoferricins, and lactoferrin-derived peptides. The primary focus is on their different mechanisms of activity against bacteria, viruses, fungi, and parasites. The role of their structure, amino-acid composition, conformation, charge, hydrophobicity, and other factors that affect their mechanisms of antimicrobial activity are also reviewed.

Ključne besede

bioaktivni peptidi;laktoferin;protimikrobno delovanje;

Podatki

Jezik: Angleški jezik
Leto izida:
Tipologija: 1.02 - Pregledni znanstveni članek
Organizacija: UL BF - Biotehniška fakulteta
UDK: 577.112:579.2
COBISS: 81567491 Povezava se bo odprla v novem oknu
ISSN: 1422-0067
Št. ogledov: 113
Št. prenosov: 36
Ocena: 0 (0 glasov)
Metapodatki: JSON JSON-RDF JSON-LD TURTLE N-TRIPLES XML RDFA MICRODATA DC-XML DC-RDF RDF

Ostali podatki

Sekundarni jezik: Slovenski jezik
Sekundarne ključne besede: bioaktivni peptidi;laktoferin;protimikrobno delovanje;
Vrsta dela (COBISS): Članek v reviji
Strani: str. 1-29
Letnik: ǂVol. ǂ22
Zvezek: ǂiss. ǂ20
Čas izdaje: 2021
DOI: 10.3390/ijms222011264
ID: 15088785