ǂat ǂthe interface of biology and drug discovery
Sandra Cetin (Avtor), Damijan Knez (Avtor), Stanislav Gobec (Avtor), Janko Kos (Avtor), Anja Pišlar (Avtor)

Povzetek

Neurodegenerative diseases are severely debilitating conditions characterized primarily by progressive neuronal loss and impairment of the nervous system. Alzheimer’s and Parkinson’s diseases are the most common neurodegenerative disorders, and their impact is increasing as average life expectancy increases worldwide. Although the underlying mechanisms of both progressive diseases have been extensively studied, we still lack a comprehensive understanding of the molecular basis of both diseases. Current therapeutic options do not slow the progression of the diseases and only provide symptom relief. Cell models that resemble the characteristics of the disease in question are important in drug discovery projects because they provide information about the therapeutic benefits of drugs under development. Here, we review current in vitro cell models used to study the molecular basis of Alzheimer’s and Parkinson’s disease focusing on their potential for discovering of disease-modifying therapeutics to combat neurodegenerative diseases. We discuss phenotypic screening as an important approach for identifying novel therapeutic molecules. Advances in the development of cell-based assays for drug discovery are discussed, ranging from simple monoculture cell models to high-throughput three-dimensional cell models. Finally, we critically present the limitations of cell models and the caveats encountered in drug discovery to find effective treatment for neurodegenerative diseases.

Ključne besede

neurodegenerative diseases;cell models;cytotoxicity assays;drug discovery;drug screening;

Podatki

Jezik: Angleški jezik
Leto izida:
Tipologija: 1.02 - Pregledni znanstveni članek
Organizacija: UL FFA - Fakulteta za farmacijo
UDK: 615.4:54:616.831-003.8
COBISS: 105487619 Povezava se bo odprla v novem oknu
ISSN: 1950-6007
Št. ogledov: 51
Št. prenosov: 23
Ocena: 0 (0 glasov)
Metapodatki: JSON JSON-RDF JSON-LD TURTLE N-TRIPLES XML RDFA MICRODATA DC-XML DC-RDF RDF

Ostali podatki

Sekundarni jezik: Slovenski jezik
Sekundarne ključne besede: nevrodegenerativne bolezni;celični modeli;preskusi citotoksičnosti;odkrivanje zdravil;Nevrodegenerativne bolezni;Alzheimerjeva bolezen;Parkinsonova bolezen;Farmacevtska kemija;
Vrsta dela (COBISS): Članek v reviji
Strani: str. 1-11
Zvezek: ǂVol. ǂ149
Čas izdaje: 2022
DOI: 10.1016/j.biopha.2022.112924
ID: 16317304