ǂa ǂstudy on ET B knockout rats
Saranda Disha Ibrahimi (Avtor), Borut Furlani (Avtor), Gorazd Drevenšek (Avtor), Alja Meh (Avtor), M Yanagisawa (Avtor), Samo Hudoklin (Avtor), Irena Prodan Žitnik (Avtor), Janja Marc (Avtor), Martina Drevenšek (Avtor)

Povzetek

The endothelin system has an important role in bone modelling during orthodontic tooth movement (OTM); however, little is known about the involvement of endothelin B receptors (ETB) in this process. The aim of this study was to evaluate the role of ETB in bone modelling during OTM using ETB knockout rats (ETB-KO). Thirty-two male rats were divided into 4 groups (n = 8 per group): the ETB-KO appliance group, ETB-KO control group, wild type (ETB-WT) appliance group, and ETB-WT control group. The appliance consisted of a super-elastic closed-coil spring placed between the first and second left maxillary molar and the incisors. Tooth movement was measured on days 0 and 35, and maxillary alveolar bone volume, osteoblast, and osteoclast volume were determined histomorphometrically on day 35 of OTM. Next, we determined the serum endothelin 1 (ET-1) level and gene expression levels of the osteoclast activity marker cathepsin K and osteoblast activity markers osteocalcin and dentin matrix acidic phosphoprotein 1 (DMP1) on day 35. The ETB-KO appliance group showed significantly lower osteoblast activity, diminished alveolar bone volume and less OTM than the ETB-WT appliance group. Our results showed that ETB is involved in bone modelling in the late stage of OTM.

Ključne besede

ortodontsko gibanje zob;endotelinski sistem;modeliranje kosti;orthodontic tooth movement;endothelin system;bone modelling;

Podatki

Jezik: Angleški jezik
Leto izida:
Tipologija: 1.01 - Izvirni znanstveni članek
Organizacija: UL MF - Medicinska fakulteta
UDK: 616.31
COBISS: 27363587 Povezava se bo odprla v novem oknu
ISSN: 2045-2322
Št. ogledov: 5
Št. prenosov: 0
Ocena: 0 (0 glasov)
Metapodatki: JSON JSON-RDF JSON-LD TURTLE N-TRIPLES XML RDFA MICRODATA DC-XML DC-RDF RDF

Ostali podatki

Sekundarni jezik: Slovenski jezik
Sekundarne ključne besede: ortodontsko gibanje zob;endotelinski sistem;modeliranje kosti;
Vrsta dela (COBISS): Članek v reviji
Strani: str. [1-11]
Zvezek: ǂVol. ǂ10
Čas izdaje: 2020
DOI: 10.1038/s41598-020-71159-8
ID: 16596529