diplomsko delo
Povzetek
Iz N-Boc-L-levcina smo po dveh različnih sinteznih poteh pripravili 2-izobutil-3-metoksipirazin (IBMP). Po prvi smo pripravili amid z 2-aminoetanolom in alkoholni del oksidirali do aldehida. Le-tega smo pod kislimi pogoji ciklizirali do pirazinona, ki smo ga klorirali in z nukleofilno aromatsko substitucijo pretvorili do končnega metoksipirazina. Po drugi sintezni poti smo iz N-Boc-L-levcina pripravili L-levcinamid. Sledila je ciklizacija z glioksalom do pirazinona. Slednjega smo nato alkilirali z metil jodidom ali pa ga, kot v prvi sintezni poti, klorirali in z nukleofilno aromatsko substitucijo pretvorili do metoksipirazina.
Ključne besede
metoksipirazini;dišave;sintezne poti;ciklizacija;diplomska dela;
Podatki
Jezik: |
Slovenski jezik |
Leto izida: |
2023 |
Tipologija: |
2.11 - Diplomsko delo |
Organizacija: |
UL FKKT - Fakulteta za kemijo in kemijsko tehnologijo |
Založnik: |
[B. Adamlje] |
UDK: |
547.86.057(043.2) |
COBISS: |
164152067
|
Št. ogledov: |
11 |
Št. prenosov: |
6 |
Ocena: |
0 (0 glasov) |
Metapodatki: |
|
Ostali podatki
Sekundarni jezik: |
Angleški jezik |
Sekundarni naslov: |
Synthesis of 2-isobutyl-3-methoxypyrazine |
Sekundarni povzetek: |
2-Isobutyl-3-methoxypyrazine (IBMP) was prepared from N-Boc-L-leucine using two different synthesis pathways. Following the first synthesis pathway, an amide was synthesized with 2-aminoethanol and then the alcohol part was oxidized to an aldehyde. Afterwards, the aldehyde was cyclized under acidic conditions to pyrazinone, which was chlorinated and converted to the final methoxypyrazine by nucleophilic aromatic substitution. Using another synthesis pathway, L-leucinamide was prepared from N-Boc-L-leucine. This was followed by cyclization with glyoxal to pyrazinone. Pyrazinone was than alkylated with methyl iodide or, as in the first synthesis pathway, chlorinated and converted into methoxypyrazine by nucleophilic aromatic substitution. |
Sekundarne ključne besede: |
fragrances;pyrazine;cyclization;Organska sinteza (kemija);Pirazin;Univerzitetna in visokošolska dela; |
Vrsta dela (COBISS): |
Diplomsko delo/naloga |
Študijski program: |
1000373 |
Konec prepovedi (OpenAIRE): |
1970-01-01 |
Komentar na gradivo: |
Univ. v Ljubljani, Fak. za kemijo in kemijsko tehnologijo, UNI Kemija |
Strani: |
34 f. |
ID: |
19908971 |