Daqing Guo (Avtor), Shengdun Wu (Avtor), Mingming Chen (Avtor), Matjaž Perc (Avtor), Yangsong Zhang (Avtor), Jingling Ma (Avtor), Yan Cui (Avtor), Peng Xu (Avtor), Yang Xia (Avtor), Dezhong Yao (Avtor)

Povzetek

The importance of self-feedback autaptic transmission in modulating spike-time irregularity is still poorly understood. By using a biophysical model that incorporates autaptic coupling, we here show that self-innervation of neurons participates in the modulation of irregular neuronal firing, primarily by regulating the occurrence frequency of burst firing. In particular, we find that both excitatory and electrical autapses increase the occurrence of burst firing, thus reducing neuronal firing regularity. In contrast, inhibitory autapses suppress burst firing and therefore tend to improve the regularity of neuronal firing. Importantly, we show that these findings are independent of the firing properties of individual neurons, and as such can be observed for neurons operating in different modes. Our results provide an insightful mechanistic understanding of how different types of autapses shape irregular firing at the single-neuron level, and they highlight the functional importance of autaptic self-innervation in taming and modulating neurodynamics.

Ključne besede

nevronska dinamika;avtapsa;regulacija;eksitacije;neuronal dynamics;autapse;regulation;excitation;

Podatki

Jezik: Angleški jezik
Leto izida:
Tipologija: 1.01 - Izvirni znanstveni članek
Organizacija: UM FNM - Fakulteta za naravoslovje in matematiko
UDK: 53
COBISS: 22210568 Povezava se bo odprla v novem oknu
ISSN: 2045-2322
Št. ogledov: 839
Št. prenosov: 355
Ocena: 0 (0 glasov)
Metapodatki: JSON JSON-RDF JSON-LD TURTLE N-TRIPLES XML RDFA MICRODATA DC-XML DC-RDF RDF

Ostali podatki

Sekundarni jezik: Slovenski jezik
Sekundarne ključne besede: nevronska dinamika;avtapsa;regulacija;eksitacije;
URN: URN:SI:UM:
Vrsta dela (COBISS): Znanstveno delo
Strani: str. 1-14
Letnik: ǂVol. ǂ6
Zvezek: ǂart. no. ǂ26096
Čas izdaje: 2016
DOI: 10.1038/srep26096
ID: 10844205