magistrsko delo
Taja Žitek (Avtor), Maša Knez Hrnčič (Mentor), Maja Leitgeb (Komentor), Barbara Dariš (Komentor)

Povzetek

Dosedanje študije so pokazale, da ima prehrana ključno vlogo pri preprečevanju kroničnih bolezni. Uživanje sadja, zelenjave, zelišč ter semen je močno povezano z manjšim tveganjem za bolezni srca in ožilja, raka, sladkorne bolezeni, Alzheimerjeve bolezni ter z zmanjšanim tveganjem za debelost. V magistrskem delu smo želeli preveriti vpliv antioksidantov, proantocianidinov in totalnih fenolov iz izbranih naravnih materialov (goji jagode, kurkuma, laneno seme, preslica, rožmarin, tropine in semena grozdja) na zmanjšanje metabolne aktivnosti rakastih celic kožnega raka. Pripravili smo raztopine izbranih naravnih materialov, jih liofilizirali in po liofilizaciji dobljenim ekstraktom izmerili koncentracijo antioksidantov, proantocianidinov in totalnih fenolov ter jih nanesli na WM-266-4 celice. Rezultati so pokazali, da so vsi ekstrakti vplivali na zaviranje rasti rakastih celic, saj so zaustavili njihovo delitev, vendar bi bile pri nekaterih ekstraktih potrebne še dodatne raziskave, še posebej pri ekstraktu lanenega semena. Najboljše rezultate pa smo zabeležili pri ekstraktu kurkume, rožmarina ter tropinah in semenu grozdja. Tem ekstraktom smo določili visok delež antioksidantov, proantocianidinov in totalnih fenolov. Predvidevamo, da je visok delež teh komponent bistven za zmanjšanje metabolne aktivnosti rakastih celic.

Ključne besede

antioksidanti;goji jagode;kurkuma;laneno seme;preslica;rožmarin;totalni fenoli;tropine;magistrske naloge;

Podatki

Jezik: Slovenski jezik
Leto izida:
Tipologija: 2.09 - Magistrsko delo
Organizacija: UM FKKT - Fakulteta za kemijo in kemijsko tehnologijo
Založnik: [T. Žitek]
UDK: 678.048(043.2)
COBISS: 21798166 Povezava se bo odprla v novem oknu
Št. ogledov: 1167
Št. prenosov: 275
Ocena: 0 (0 glasov)
Metapodatki: JSON JSON-RDF JSON-LD TURTLE N-TRIPLES XML RDFA MICRODATA DC-XML DC-RDF RDF

Ostali podatki

Sekundarni jezik: Angleški jezik
Sekundarni naslov: The influence of extracts from natural materials on the metabolic activity of human melanoma cells (WM-266-4)
Sekundarni povzetek: Several studies have demonstrated that diet has a important role in the prevention of chronic diseases. The consumption of fruits, vegetables, herbs and grains is strongly associated with a lower risk of cardiovascular disease, cancer, diabetes, Alzheimer's disease and reduced risk of obesity. The main goal of the master's thesis has been to check the correlation between the content of antioxidants, proanthocyanidins and total phenolics in the selected natural materials (goji berries, turmeric, flaxseed, carrots, rosemary, troipins and grape seeds) and the reduction of the metabolic activity of skin cancer cells. The solutions of the selected natural materials were lyophilized. After lyophilization, the concentration of antioxidants, proanthocyanidins and total phenol was measured and the extract solution was applied to WM-266-4 cells. The results showed that all the extracts affected cancer cells and stopped their further divisions, but some extracts would require further research, especially the extract of flaxseed, where the metabolic activity of the cells was barely noticed. The highest reduction of the metabolic activity of cancer cells was noticed for the extracts of turmeric, rosemary and grape marc extracts. Those extracts contained high concentrations of antioxidants, proanthocyanidins and total phenolics and proofed positive effects on the reduction of the metabolic activity of cancer cells.
Sekundarne ključne besede: antioxidants;goji berry;curcuma;flax seed;horsetail;proanthocyanidis;rosemary;total phenols;grape seed;
URN: URN:SI:UM:
Vrsta dela (COBISS): Magistrsko delo/naloga
Komentar na gradivo: Univ. v Mariboru, Fak. za kemijo in kemijsko tehnologijo
Strani: XI, 45 str.
ID: 10955492