magistrsko delo
Andrej Lozar (Avtor), Matija Milanič (Mentor), Matjaž Lukač (Komentor)

Povzetek

V magistrski nalogi smo raziskovali delovanje različnih modelov poškodb biološkega tkiva, ki nastanejo zaradi izpostavljenosti visokim temperaturam. Vsi temeljijo na poznavanju temperature tkiva. Nekateri so neposredno odvisni od temperature, posredno odvisne pa smo nadgradili, da so postali neposredno odvisni. Različna tkiva se različno odzivajo na povišanje lastne temperature, zato so za opis različnih tkiv primerni različni modeli. Da bi primerjali uspešnost in primernost, smo modele testirali na meritvah preživetja celic oziroma tkiv in na meritvah kritične temperature v odvisnosti od časa ekspozicije (Arrheniusova krivulja). Tako smo izračunali tkivne parametre za vse uporabljene modele in jih primerjali z že objavljenimi. Zanimalo nas je tudi, ali je kateri izmed modelov vsestransko uporaben. Za opis Arrheniusovih krivulj se je najbolje izkazal VHS in nato model denaturacije encimov, za splošen opis vseh meritev pa verjetnostni model izgube klonogenosti. Vsak model je lastne meritve opisal zelo dobro. Le v enem primeru, kjer so model naredili na podlagi lastnih meritev, se je izkazalo, da en drug model te iste meritve opiše še boljše.

Ključne besede

medicinska fizika;biološka tkiva;poškodbe celic;poškodbe tkiv;termalna dozimetrija;

Podatki

Jezik: Slovenski jezik
Leto izida:
Tipologija: 2.09 - Magistrsko delo
Organizacija: UL FMF - Fakulteta za matematiko in fiziko
Založnik: [A. Lozar]
UDK: 615.849
COBISS: 3370852 Povezava se bo odprla v novem oknu
Št. ogledov: 673
Št. prenosov: 222
Ocena: 0 (0 glasov)
Metapodatki: JSON JSON-RDF JSON-LD TURTLE N-TRIPLES XML RDFA MICRODATA DC-XML DC-RDF RDF

Ostali podatki

Sekundarni jezik: Angleški jezik
Sekundarni naslov: Comparison of thermal damage models of tissues for medical laser procedures
Sekundarni povzetek: In this master thesis we investigate various models of biological tissue damage resulting from exposure to high temperatures. All models are based on knowing the tissue's temperature. Some of them are directly temperature dependant and some are indirectly dependant. The latter have been upgraded to become directly temperature dependant as well. Different tissues respond differently to an increase in their own temperature, therefore different models are appropriate to describe different tissue. In order to compare performance and suitability, we tested the models on cell and tissue viability measurements and critical temperature measurements as a function of exposure time (Arrhenius curve). Thus, we calculated the tissue parameters for all the models used and compared them with those already published. We also wanted to know if any of the models were versatile. VHS model followed by enzyme denaturation model were best suited for describing the Arrhenius curves and heat-induced clonogenic cell death model for the overall description of all measurements. Each model described its own measurements very well. In only one case where the model was made on the basis of their own measurements, it turned out that another model described these same measurements even better.
Sekundarne ključne besede: medical physics;biological tissues;cell injuries;tissue injuries;thermal dosimetry;
Vrsta dela (COBISS): Magistrsko delo/naloga
Študijski program: 0
Konec prepovedi (OpenAIRE): 1970-01-01
Komentar na gradivo: Univ. v Ljubljani, Fak. za matematiko in fiziko, Oddelek za fiziko
Strani: 152 str.
ID: 11224184