analysis of a large observational database
Jean Louis Vincent (Avtor), Andrew Ferguson (Avtor), Peter Pickkers (Avtor), Stephan M. Jakob (Avtor), Ulrich Jaschinski (Avtor), Ghaleb A. Almekhlafi (Avtor), Marc Leone (Avtor), Majid Mokhtari (Avtor), Luis E. Fontes (Avtor), Philippe R. Bauer (Avtor), Yasser Sakr (Avtor), Gorazd Voga (Sodelavec pri raziskavi), Erik Rupnik (Sodelavec pri raziskavi), Lučka Kosec (Sodelavec pri raziskavi), Milena Kerin-Povšič (Sodelavec pri raziskavi), Irena Osojnik (Sodelavec pri raziskavi), Viktorija Tomič (Sodelavec pri raziskavi), Andreja Sinkovič (Sodelavec pri raziskavi)

Povzetek

Background: Urine output is widely used as one of the criteria for the diagnosis and staging of acute renal failure, but few studies have specifically assessed the role of oliguria as a marker of acute renal failure or outcomes in general intensive care unit (ICU) patients. Using a large multinational database, we therefore evaluated the occurrence of oliguria (defined as a urine output < 0.5 ml/kg/h) in acutely ill patients and its association with the need for renal replacement therapy (RRT) and outcome. Methods: International observational study. All adult (> 16 years) patients in the ICON audit who had a urine output measurement on the day of admission were included. To investigate the association between oliguria and mortality, we used a multilevel analysis. Results: Of the 8292 patients included, 2050 (24.7%) were oliguric during the first 24 h of admission. Patients with oliguria on admission who had at least one additional 24-h urine output recorded during their ICU stay (n = 1349) were divided into three groups: transient-oliguria resolved within 48 h after the admission day (n = 390 [28.9%]), prolonged-oliguria resolved > 48 h after the admission day (n = 141 [10.5%]), and permanent-oliguria persisting for the whole ICU stay or again present at the end of the ICU stay (n = 818 [60.6%]). ICU and hospital mortality rates were higher in patients with oliguria than in those without, except for patients with transient oliguria who had significantly lower mortality rates than non-oliguric patients. In multilevel analysis, the need for RRT was associated with a significantly higher risk of death (OR = 1.51 [95% CI 1.19%1.91], p = 0.001), but the presence of oliguria on admission was not (OR = 1.14 [95% CI 0.97%1.34], p = 0.103). Conclusions: Oliguria is common in ICU patients and may have a relatively benign nature if only transient. The duration of oliguria and need for RRT are associated with worse outcome.

Ključne besede

izločanje urina;nadomestno zdravljenje ledvične odpovedi;urine output;renal replacement therapy;

Podatki

Jezik: Angleški jezik
Leto izida:
Tipologija: 1.01 - Izvirni znanstveni članek
Založnik: Springer Nature
UDK: 616.1/.4
COBISS: 37575171 Povezava se bo odprla v novem oknu
ISSN: 1466-609X
Št. ogledov: 899
Št. prenosov: 542
Ocena: 0 (0 glasov)
Metapodatki: JSON JSON-RDF JSON-LD TURTLE N-TRIPLES XML RDFA MICRODATA DC-XML DC-RDF RDF

Ostali podatki

Sekundarne ključne besede: Critical care;Critical illness;Urine;Oliguria;Kidney;Renal insufficiency;Kidney diseases;Kidney failure, acute;Mortality;Oskrba kritično bolnih;Kritično stanje;Urin;Oligurija;Ledvica;Renalna insuficienca;Bolezni ledvic;Akutna ledvična odpoved;Umrljivost;
Komentar vira: Nasl. z nasl. zaslona; Opis vira z dne 16. 11. 2020; Sodelavci pri raziskavi iz Slovenije: Gorazd Voga, Erik Rupnik, Lucka Kosec, Milena Kerin Povšic, Irena Osojnik, Viktorija Tomic, Andreja Sinkovic; Article no. 171;
Strani: str. 1-14
Zvezek: ǂVol. ǂ24
Čas izdaje: 2020
DOI: 10.1186/s13054-020-02858-x
ID: 12168689