Ana Nemec (Avtor), Nina Milevoj (Avtor), Urša Lampreht Tratar (Avtor), Gregor Serša (Avtor), Maja Čemažar (Avtor), Nataša Tozon (Avtor)

Povzetek

Electroporation is a method of inducing an increase in permeability of the cell membrane through the application of an electric field and can be used as a delivery method for introducing molecules of interest (e.g., chemotherapeutics or plasmid DNA) into cells. Electroporation-based treatments (i.e., electrochemotherapy, gene electrotransfer, and their combinations) have been shown to be safe and effective in veterinary oncology, but they are currently mostly recommended for the treatment of those solid tumors for which clients have declined surgery and/or radiotherapy. Published data show that electroporation-based treatments are also safe, simple, fast and cost-effective treatment alternatives for selected oral and maxillofacial tumors, especially small squamous cell carcinoma and malignant melanoma tumors not involving the bone in dogs. In these patients, a good local response to treatment is expected to result in increased survival time with good quality of life. Despite emerging evidence of the clinical efficacy of electroporation-based treatments for oral and maxillofacial tumors, further investigation is needed to optimize treatment protocols, improve clinical data reporting and better understand the mechanisms of patients' response to the treatment.

Ključne besede

Electroporation;electrochemotherapy (ECT);gene electrotransfer;oral tumors;dog;cats;

Podatki

Jezik: Angleški jezik
Leto izida:
Tipologija: 1.02 - Pregledni znanstveni članek
Organizacija: UL VF - Veterinarska fakulteta
UDK: 636.09:616
COBISS: 30212611 Povezava se bo odprla v novem oknu
ISSN: 2297-1769
Št. ogledov: 332
Št. prenosov: 98
Ocena: 0 (0 glasov)
Metapodatki: JSON JSON-RDF JSON-LD TURTLE N-TRIPLES XML RDFA MICRODATA DC-XML DC-RDF RDF

Ostali podatki

Sekundarne ključne besede: Electroporation;Electrochemotherapy;Mouth Neoplasms;Dogs;Cats;
Vrsta dela (COBISS): Članek v reviji
Strani: art. 575911, str. 1-17
Zvezek: ǂVol. ǂ7
Čas izdaje: 2020
DOI: 10.3389/fvets.2020.575911
ID: 12174532