Reproducibility of malignant pleural mesothelioma histopathologic subtyping

Luka Brčić (Avtor), Gregor Vlačić (Avtor), Franz Quehenberger (Avtor), Izidor Kern (Avtor)

Povzetek

Context. Malignant pleural mesothelioma (MPM) is a rare tumor with poor prognosis. Several studies have analyzed potential prognostic markers, but histologic type remains the single most important prognostic factor. Histologic subtypes of epithelioid MPM seem to have prognostic and therapeutic implications. Interobserver agreement in histologic pattern classification should be high. Objective. To assess interobserver and intraobserver reproducibility in histologic differentiation between the main types of MPMs, and in further subtyping of epithelioid-type mesothelioma. Design. One representative hematoxylin-eosin-stained slide was selected from the archive for each of 200 patients with MPM. They were reviewed independently by 3 pathologists and classified according to the current World Health Organization classification of pleural tumors. After the first round of evaluations, a consensus meeting was organized where problems were addressed and representative images for each histologic category were selected. Two months later, cases were reevaluated by all 3 pathologists. Results. After the first round, overall interobserver agreement for histologic subtyping of mesothelioma was fair (k, 0.36). The agreement was increased to substantial (k, 0.63) in the second round. Improvement was found in interobserver agreement for all types of MPM, and for most epithelioid subtypes. Conclusions. Moderate to substantial agreement in histologic typing and subtyping of MPM can be achieved. However, training with additional clarification of diagnostic criteria, their strict application, and help from consensus-based illustrative images is needed.

Ključne besede

malignant pleural mesothelioma;histopathology;

Podatki

Jezik:	Angleški jezik
Leto izida:	2018
Tipologija:	1.01 - Izvirni znanstveni članek
Založnik:	College of American Pathologists
UDK:	616-006
COBISS:	2048255345
ISSN:	1543-2165
Št. ogledov:	5389
Št. prenosov:	210
Ocena:	0 (0 glasov)
Metapodatki:

Ostali podatki

Sekundarne ključne besede:	maligni plevralni mezoteliom;histopatologija;Neoplasms, connective and soft tissue;Pathology;Novotvorbe vezivnih in mehkih tkiv;Patologija;
Komentar vira:	Soavtorji: Gregor Vlacic, Franz Quehenberger, Izidor Kern; Nasl. z nasl. zaslona; Opis vira z dne 8. 3. 2018;
Strani:	str. 747-752
Letnik:	ǂVol. ǂ142
Zvezek:	ǂiss. ǂ6
Čas izdaje:	2018
DOI:	10.5858/arpa.2017-0295-OA
ID:	12204574