Iztok Dogša (Avtor), Mihael Špacapan (Avtor), Anna Oslizlo (Avtor), Tjaša Danevčič (Avtor), Žiga Pandur (Avtor), Ines Mandić-Mulec (Avtor)

Povzetek

Bacterial quorum sensing (QS) is based on signal molecules (SM), which increase in concentration with cell density. At critical SM concentration, a variety of adaptive genes sharply change their expression from basic level to maximum level. In general, this sharp transition, a hallmark of true QS, requires an SM dependent positive feedback loop, where SM enhances its own production. Some communication systems, like the peptide SM-based ComQXPA communication system of Bacillus subtilis, do not have this feedback loop and we do not understand how and if the sharp transition in gene expression is achieved. Based on experiments and mathematical modeling, we observed that the SM peptide ComX encodes the information about cell density, specific cell growth rate, and even oxygen concentration, which ensure power-law increase in SM production. This enables together with the cooperative response to SM (ComX) a sharp transition in gene expression level and this without the SM dependent feedback loop. Due to its ultra-sensitive nature, the ComQXPA can operate at SM concentrations that are 100–1000 times lower than typically found in other QS systems, thereby substantially reducing the total metabolic cost of otherwise expensive ComX peptide.

Ključne besede

Bacillus subtilis;komunikacija med celicami;zaznavanje kvoruma;signalni peptidi;

Podatki

Jezik: Angleški jezik
Leto izida:
Tipologija: 1.01 - Izvirni znanstveni članek
Organizacija: UL BF - Biotehniška fakulteta
UDK: 579.22/.26:579.852.1
COBISS: 47412483 Povezava se bo odprla v novem oknu
ISSN: 2399-3642
Št. ogledov: 448
Št. prenosov: 218
Ocena: 0 (0 glasov)
Metapodatki: JSON JSON-RDF JSON-LD TURTLE N-TRIPLES XML RDFA MICRODATA DC-XML DC-RDF RDF

Ostali podatki

Sekundarni jezik: Slovenski jezik
Sekundarne ključne besede: Bacillus subtilis;komunikacija med celicami;zaznavanje kvoruma;signalni peptidi;
Vrsta dela (COBISS): Članek v reviji
Strani: str. 1-12
Zvezek: ǂVol. ǂ4
Čas izdaje: 2021
DOI: 10.1038/s42003-020-01553-5
ID: 12717713