Vloga elektrostatskih interakcij v proteinskih sistemih

diplomsko delo

Adela Avdičević (Avtor), Miha Lukšič (Mentor)

Povzetek

V svoji diplomski nalogi sem se osredotočila na vlogo elektrostatskih interakcij v proteinskih sistemih. Orisala sem dva implicitna teoretična modela za obravnavo elektrostatike pri proteinih: Bornov in Poisson-Boltzmannov model. Elektrostatske interakcije so pri proteinih močno odvisne od njihove zgradbe, pa tudi od pH raztopine, temperature, prisotnosti soli in kofaktorjev. Igrajo zelo pomembno vlogo (zlasti vodikova vez in solni mostički) na zvijanje in s tem na strukturo proteinov. Pomembne so tudi za topnost proteinov, interakcije proteinov z drugimi biološkimi molekulami ter interakcije protein-protein, zaradi katerih pride do samozdruževanja le-teh. Proteini se lahko tudi napačno zvijejo, kar vodi do agregacije. Ti agregati se začnejo kopičiti v tkivu, zaradi česa celica ne more več opravljati svoje funkcije, kar vodi do nastanka nevrodegenerativnih bolezni. Te bolezni so danes zelo razširjene, na žalost pa so še vedno neozdravljive.

Ključne besede

proteini;aminokisline;elektrostatske interakcije;vodikova vez;solni mostički;protein-protein interakcije;Hofmeistrova vrsta;agregacija proteinov;diplomska dela;

Podatki

Jezik:	Slovenski jezik
Leto izida:	2021
Tipologija:	2.11 - Diplomsko delo
Organizacija:	UL FKKT - Fakulteta za kemijo in kemijsko tehnologijo
Založnik:	[A. Avdičević]
UDK:	577.322(043.2)
COBISS:	81929219
Št. ogledov:	282
Št. prenosov:	37
Ocena:	0 (0 glasov)
Metapodatki:

Ostali podatki

Sekundarni jezik:	Angleški jezik
Sekundarni naslov:	The role of electrostatic interactions in protein systems
Sekundarni povzetek:	In my diploma, I focused on the role of electrostatic interactions in protein systems. Outline of two implicit theoretical models used for treating electrostatics in systems containing proteins will be given: the Born and the Poisson-Boltzmann model. Electrostatic interactions are strongly dependent on the protein composition, as well as on pH, temperature, presence of salts, and cofactors. They play a very important role (especially hydrogen bonding and salt bridges) in folding and thus in protein structure. They are also important for protein solubility, protein interactions with other biological molecules, and protein-protein interactions that lead to protein self-aggregation, as proteins in the vast majority of cases do not act on their own. Proteins can also be misfolded, which leads to protein aggregation. These aggregates begin to accumulate in the tissue, causing the cell to no longer be able to perform its function, leading to the development of neurodegenerative diseases. These diseases are very common today, but unfortunately they are still not curable
Sekundarne ključne besede:	proteins;amino acids;electrostatic interactions;hydrogen bonding;salt bridges;protein-protein interactions;Hofmeister series;protein aggregation;
Vrsta dela (COBISS):	Diplomsko delo/naloga
Študijski program:	1000373
Konec prepovedi (OpenAIRE):	1970-01-01
Komentar na gradivo:	Univ. v Ljubljani, Fak. za kemijo in kemijsko tehnologijo, UNI Kemija
Strani:	35 str.
ID:	13345802