Astrocytic pathological calcium homeostasis and impaired vesicle trafficking in neurodegeneration

Nina Vardjan (Avtor), Alexei Verkhratsky (Avtor), Robert Zorec (Avtor)

Povzetek

Although the central nervous system (CNS) consists of highly heterogeneous populations of neurones and glial cells, clustered into diverse anatomical regions with specific functions, there are some conditions, including alertness, awareness and attention that require simultaneous, coordinated and spatially homogeneous activity within a large area of the brain. During such events, the brain, representing only about two percent of body mass, but consuming one fifth of body glucose at rest, needs additional energy to be produced. How simultaneous energy procurement in a relatively extended area of the brain takes place is poorly understood. This mechanism is likely to be impaired in neurodegeneration, for example in Alzheimer%s disease, the hallmark of which is brain hypometabolism. Astrocytes, the main neural cell type producing and storing glycogen, a form of energy in the brain, also hold the key to metabolic and homeostatic support in the central nervous system and are impaired in neurodegeneration, contributing to the slow decline of excitation-energy coupling in the brain. Many mechanisms are affected, including cell-to-cell signalling. An important question is how changes in cellular signalling, a process taking place in a rather short time domain, contribute to the neurodegeneration that develops over decades. In this review we focus initially on the slow dynamics of Alzheimer%s disease, and on the activity of locus coeruleus, a brainstem nucleus involved in arousal. Subsequently, we overview much faster processes of vesicle traffic and cytosolic calcium dynamics, both of which shape the signalling landscape of astrocyte-neurone communication in health and neurodegeneration.

Ključne besede

Alzheimerjeva bolezen;Parkinsonova bolezen;nevrodegeneracija;Alzheimer's disease;Parkinson's disease;neurodegeneration;

Podatki

Jezik:	Angleški jezik
Leto izida:	2017
Tipologija:	1.02 - Pregledni znanstveni članek
Organizacija:	UL MF - Medicinska fakulteta
UDK:	616.8
COBISS:	33094617
ISSN:	1422-0067
Št. ogledov:	235
Št. prenosov:	69
Ocena:	0 (0 glasov)
Metapodatki:

Ostali podatki

Sekundarni jezik:	Slovenski jezik
Sekundarne ključne besede:	Alzheimerjeva bolezen;Parkinsonova bolezen;nevrodegeneracija;
Vrsta dela (COBISS):	Članek v reviji
Strani:	str. 1-19
Letnik:	ǂVol. ǂ18
Zvezek:	ǂiss. ǂ2
Čas izdaje:	Feb. 2017
DOI:	10.3390/ijms18020358
ID:	13539699