Petra Bogovič (Avtor), Lara Lusa (Avtor), Miša Korva (Avtor), Miša Marušić (Avtor), Katarina Resman Rus (Avtor), Stanka Lotrič-Furlan (Avtor), Tatjana Avšič-Županc (Avtor), Klemen Strle (Avtor), Franc Strle (Avtor)

Povzetek

Clinical manifestations of tick-borne encephalitis (TBE) are thought to result from the host immune responses to infection, but knowledge of such responses is incomplete. We performed a detailed clinical evaluation and characterization of innate and adaptive inflammatory immune responses in matched serum and cerebrospinal fluid (CSF) samples from 81 adult patients with TBE. Immune responses were then correlated with laboratory and clinical findings. The inflammatory immune responses were generally site-specific. Cytokines and chemokines associated with innate and Th1 adaptive immune responses were significantly higher in CSF, while mediators associated with Th17 and B-cell responses were generally higher in serum. Furthermore, mediators associated with innate and Th1 adaptive immune responses were positively associated with disease severity, whereas Th17 and B cell immune responses were not. During the meningoencephalitic phase of TBE, innate and Th1 adaptive inflammatory mediators were highly concentrated in CSF, the site of the disease. The consequence of this robust immune response was more severe acute illness. In contrast, inflammatory mediators associated with B cell and particularly Th17 responses were concentrated in serum. These findings provide new insights into the immunopathogenesis of TBE and implicate innate and Th1 adaptive responses in severity and clinical presentation of acute illness.

Ključne besede

tick-borne encephalitis;inflammatory mediators;innate immunity;adaptive immunity;cytokines;chemokines;cerebrospinal fluid;severity of illness;

Podatki

Jezik: Angleški jezik
Leto izida:
Tipologija: 1.01 - Izvirni znanstveni članek
Organizacija: UL MF - Medicinska fakulteta
UDK: 616.9
COBISS: 6109612 Povezava se bo odprla v novem oknu
ISSN: 2077-0383
Št. ogledov: 203
Št. prenosov: 58
Ocena: 0 (0 glasov)
Metapodatki: JSON JSON-RDF JSON-LD TURTLE N-TRIPLES XML RDFA MICRODATA DC-XML DC-RDF RDF

Ostali podatki

Vrsta dela (COBISS): Članek v reviji
Strani: str. 1-16
Letnik: ǂVol. ǂ8
Zvezek: ǂiss. ǂ5
Čas izdaje: 2019
DOI: 10.3390/jcm8050731
ID: 13545843