Miša Korva (Avtor), Katarina Resman Rus (Avtor), Miša Marušić (Avtor), Ana Saksida (Avtor), Nataša Knap (Avtor), Mateja Jelovšek (Avtor), Katja Strašek (Avtor), Xhevat Jakupi (Avtor), Miroslav Petrovec (Avtor), Tatjana Avšič-Županc (Avtor)

Povzetek

Hemorrhagic fever with renal syndrome (HFRS) and Crimean-Congo hemorrhagic fever (CCHF) are important viral hemorrhagic fevers (VHF), especially in the Balkan region. Infections with Dobrava or Puumala orthohantavirus and Crimean-Congo hemorrhagic fever orthonairovirus can vary from a mild, nonspecific febrile illness, to a severe disease with a fatal outcome. The pathogenesis of both diseases is poorly understood, but it has been suggested that a host's immune mechanism might influence the pathogenesis of the diseases and survival. The aim of our study is to characterize cytokine response in patients with VHF in association with the disease progression and viral load. Forty soluble mediators of the immune response, coagulation, and endothelial dysfunction were measured in acute serum samples in 100 HFRS patients and 70 CCHF patients. HFRS and CCHF patients had significantly increased levels of IL-6, IL-12p70, IP-10, INF-[gamma], TNF-[alpha], GM-CSF, MCP-3, and MIP-1b in comparison to the control group. Interestingly, HFRS patients had higher concentrations of serum MIP-1[alpha], MIP-1[beta], which promote activation of macrophages and NK cells. HFRS patients had increased concentrations of IFN-[gamma] and TNF-[alpha], while CCHF patients had significantly higher concentrations of IFN-[alpha] and IL-8. In both, CCHF and HFRS patients' viral load significantly correlated with IP-10. Patients with fatal outcome had significantly elevated concentrations of IL-6, IFN-[alpha]2 and MIP-1[alpha], while GRO-[alpha], chemokine related to activation of neutrophils and basophils, was downregulated. Our study provided a comprehensive characterization of biomarkers released in the acute stages of CCHF and HFRS.

Ključne besede

Crimean-Congo hemorrhagic fever;hantavirus fever;biomarkers;

Podatki

Jezik: Angleški jezik
Leto izida:
Tipologija: 1.01 - Izvirni znanstveni članek
Organizacija: UL MF - Medicinska fakulteta
UDK: 616.9
COBISS: 34443481 Povezava se bo odprla v novem oknu
ISSN: 1999-4915
Št. ogledov: 208
Št. prenosov: 73
Ocena: 0 (0 glasov)
Metapodatki: JSON JSON-RDF JSON-LD TURTLE N-TRIPLES XML RDFA MICRODATA DC-XML DC-RDF RDF

Ostali podatki

Sekundarni jezik: Slovenski jezik
Sekundarne ključne besede: krimsko-kongoška hemoragična mrzlica;hantavirusna mrzlica;biomarkerji;
Vrsta dela (COBISS): Članek v reviji
Strani: str. 1-19
Letnik: ǂVol. ǂ11
Zvezek: ǂiss. ǂ8
Čas izdaje: 2019
DOI: 10.3390/v11080686
ID: 13826371