An overview of crucial dietary substances and their modes of action for prevention of neurodegenerative diseases

Lea Pogačnik (Avtor), Ajda Ota (Avtor), Nataša Poklar Ulrih (Avtor)

Povzetek

Neurodegenerative diseases, namely Alzheimer’s disease (AD), Parkinson’s disease (PD), amyotrophic lateral sclerosis, Huntington’s disease, and multiple sclerosis are becoming one of the main health concerns due to the increasing aging of the world’s population. These diseases often share the same biological mechanisms, including neuroinflammation, oxidative stress, and/or protein fibrillation. Recently, there have been many studies published pointing out the possibilities to reduce and postpone the clinical manifestation of these deadly diseases through lifelong consumption of some crucial dietary substances, among which phytochemicals (e.g., polyphenols) and endogenous substances (e.g., acetyl-L-carnitine, coenzyme Q10, n-3 poysaturated fatty acids) showed the most promising results. Another important issue that has been pointed out recently is the availability of these substances to the central nervous system, where they have to be present in high enough concentrations in order to exhibit their neuroprotective properties. As so, such the aim of this review is to summarize the recent findings regarding neuroprotective substances, their mechanisms of action, as well as to point out therapeutic considerations, including their bioavailability and safety for humans.

Ključne besede

prehrana;živila;naravne snovi;bioaktivne spojine;fenolne spojine;polifenoli;nevroprotektivne snovi;oksidativni stres;rastlinski ekstrakti;sadje;zelenjava;zeleni čaj;kurkumin;zdravilne učinkovine;nevrodegenerativne bolezni;

Podatki

Jezik:	Angleški jezik
Leto izida:	2020
Tipologija:	1.02 - Pregledni znanstveni članek
Organizacija:	UL BF - Biotehniška fakulteta
UDK:	547.9:547.56:616.8
COBISS:	5172856
ISSN:	2073-4409
Št. ogledov:	181
Št. prenosov:	62
Ocena:	0 (0 glasov)
Metapodatki:

Ostali podatki

Sekundarni jezik:	Slovenski jezik
Sekundarne ključne besede:	prehrana;živila;naravne snovi;bioaktivne spojine;fenolne spojine;polifenoli;nevroprotektivne snovi;oksidativni stres;rastlinski ekstrakti;sadje;zelenjava;zeleni čaj;kurkumin;zdravilne učinkovine;nevrodegenerativne bolezni;
Vrsta dela (COBISS):	Članek v reviji
Strani:	str. 1-25
Letnik:	ǂVol. ǂ9
Zvezek:	ǂiss. ǂ3
Čas izdaje:	2020
DOI:	10.3390/cells9030576
ID:	13961676