Current view on EpCAM structural biology

Aljaž Gaber (Avtor), Brigita Lenarčič (Avtor), Miha Pavšič (Avtor)

Povzetek

EpCAM, a carcinoma cell-surface marker protein and a therapeutic target, has been primarily addressed as a cell adhesion molecule. With regard to recent discoveries of its role in signaling with implications in cell proliferation and differentiation, and findings contradicting a direct role in mediating adhesion contacts, we provide a comprehensive and updated overview on the available structural data on EpCAM and interpret it in the light of recent reports on its function. First, we describe the structure of extracellular part of EpCAM, both as a subunit and part of a cis-dimer which, according to several experimental observations, represents a biologically relevant oligomeric state. Next, we provide a thorough evaluation of reports on EpCAM as a homophilic cell adhesion molecule with a structure-based explanation why direct EpCAM participation in cell–cell contacts is highly unlikely. Finally, we review the signaling aspect of EpCAM with focus on accessibility of signaling-associated cleavage sites.

Ključne besede

EpCAM;transmembranski proteini;struktura;dimer;adhezija;regulirana znotrajmembranska proteoliza;signaliziranje;bolezni;transmembrane protein;structure;adhesion;regulated intramembrane proteolysis;signaling;disease;

Podatki

Jezik:	Angleški jezik
Leto izida:	2020
Tipologija:	1.02 - Pregledni znanstveni članek
Organizacija:	UL FKKT - Fakulteta za kemijo in kemijsko tehnologijo
UDK:	577.112
COBISS:	17857539
ISSN:	2073-4409
Št. ogledov:	199
Št. prenosov:	55
Ocena:	0 (0 glasov)
Metapodatki:

Ostali podatki

Sekundarni jezik:	Slovenski jezik
Sekundarne ključne besede:	EpCAM;transmembranski proteini;struktura;dimer;adhezija;regulirana znotrajmembranska proteoliza;signaliziranje;bolezni;
Vrsta dela (COBISS):	Članek v reviji
Strani:	str. 1-18
Letnik:	ǂVol. ǂ9
Zvezek:	ǂiss. ǂ6
Čas izdaje:	Jun. 2020
DOI:	10.3390/cells9061361
ID:	14067391