Arpad Mihai Rostas (Avtor), Mihaela Badea (Avtor), Lavinia L. Ruţǎ (Avtor), Ileana C. Farcaşanu (Avtor), Cǎtǎlin Maxim (Avtor), Mariana Carmen Chifiriuc (Avtor), Rodica Olar (Avtor), Marcela Popa (Avtor), Mirela Luca (Avtor), Nataša Čelan Korošin (Avtor), Romana Cerc Korošec (Avtor), Mihaela Bacalum (Avtor), Mina Raileanu (Avtor)

Povzetek

Complexes with mixed ligands [Cu(N-N)$_2$(pmtp)](ClO$_4$)$_2$ ((1) N-N: 2,2′-bipyridine; (2) L: 1,10-phenanthroline and pmpt: 5-phenyl-7-methyl-1,2,4-triazolo[1,5-a]pyrimidine) were synthesized and structurally and biologically characterized. Compound (1) crystallizes into space group Pa and (2) in P-1. Both complexes display an intermediate stereochemistry between the two five-coordinated ones. The biological tests indicated that the two compounds exhibited superoxide scavenging capacity, intercalative DNA properties, and metallonuclease activity. Tests on various cell systems indicated that the two complexes neither interfere with the proliferation of Saccharomyces cerevisiae or BJ healthy skin cells, nor cause hemolysis in the active concentration range. Nevertheless, the compounds showed antibacterial potential, with complex (2) being significantly more active than complex (1) against all tested bacterial strains, both in planktonic and biofilm growth state. Both complexes exhibited a very good activity against B16 melanoma cells, with a higher specificity being displayed by compound (1). Taken together, the results indicate that complexes (1) and (2) have specific biological relevance, with potential for the development of antitumor or antimicrobial drugs.

Ključne besede

baker;bakrovi kompleksi;1,2,4-triazolo[1,5-a]pirimidin;citotoksičnost;copper(II) complex;1,2,4-triazolo[1,5-a]pyrimidine;cytotoxicity;biofilm;metallonuclease activity;DNA intercalation;

Podatki

Jezik: Angleški jezik
Leto izida:
Tipologija: 1.01 - Izvirni znanstveni članek
Organizacija: UL FKKT - Fakulteta za kemijo in kemijsko tehnologijo
UDK: 546.56:547.853
COBISS: 26455043 Povezava se bo odprla v novem oknu
ISSN: 1420-3049
Št. ogledov: 179
Št. prenosov: 58
Ocena: 0 (0 glasov)
Metapodatki: JSON JSON-RDF JSON-LD TURTLE N-TRIPLES XML RDFA MICRODATA DC-XML DC-RDF RDF

Ostali podatki

Sekundarni jezik: Slovenski jezik
Sekundarne ključne besede: baker;bakrovi kompleksi;1;2;4-triazolo[1;5-a]pirimidin;citotoksičnost;
Vrsta dela (COBISS): Članek v reviji
Strani: str. 1-22
Letnik: ǂVol. ǂ25
Zvezek: ǂiss. ǂ17
Čas izdaje: Sep. 2020
DOI: 10.3390/molecules25173777
ID: 14240282