CARD8 and IL1B polymorphisms influence MRI brain patterns in newborns with hypoxic-ischemic encephalopathy treated with hypothermia

Katarina Esih (Avtor), Katja Goričar (Avtor), Zvonka Rener-Primec (Avtor), Vita Dolžan (Avtor), Aneta Soltirovska Šalamon (Avtor)

Povzetek

Inflammation and oxidative stress are recognized as important contributors of brain injury in newborns due to a perinatal hypoxic-ischemic (HI) insult. Genetic variability in these pathways could influence the response to HI and the outcome of brain injury. The aim of our study was to evaluate the impact of common single-nucleotide polymorphisms in the genes involved in inflammation and response to oxidative stress on brain injury in newborns after perinatal HI insult based on the severity and pattern of magnetic resonance imaging (MRI) findings. The DNA of 44 subjects was isolated from buccal swabs. Genotyping was performed for NLRP3 rs35829419, CARD8 rs2043211, IL1B rs16944, IL1B rs1143623, IL1B rs1071676, TNF rs1800629, CAT rs1001179, SOD2 rs4880, and GPX1 rs1050450. Polymorphism in CARD8 was found to be protective against HI brain injury detected by MRI overall findings. Polymorphisms in IL1B were associated with posterior limb of internal capsule, basal ganglia, and white matter brain patterns determined by MRI. Our results suggest a possible association between genetic variability in inflammation- and antioxidant-related pathways and the severity of brain injury after HI insult in newborns.

Ključne besede

hypoxic-ischemic encephalopathy;inflammation;newborn;

Podatki

Jezik:	Angleški jezik
Leto izida:	2021
Tipologija:	1.01 - Izvirni znanstveni članek
Organizacija:	UL MF - Medicinska fakulteta
UDK:	616-002
COBISS:	47469571
ISSN:	2076-3921
Št. ogledov:	171
Št. prenosov:	38
Ocena:	0 (0 glasov)
Metapodatki:

Ostali podatki

Sekundarni jezik:	Slovenski jezik
Sekundarne ključne besede:	hipoksično-ishemična encefalopatija;vnetje;novorojenček;
Vrsta dela (COBISS):	Članek v reviji
Strani:	str. [1]-14
Letnik:	ǂVol. ǂ10
Zvezek:	ǂiss. ǂ1
Čas izdaje:	2021
DOI:	10.3390/antiox10010096
ID:	14418269