Zerrin Sezgin-Bayindir (Avtor), Sonia Losada-Barreiro (Avtor), Carlos Bravo-Díaz (Avtor), Matej Sova (Avtor), Julijana Kristl (Avtor), Luciano Saso (Avtor)

Povzetek

The disadvantages of conventional anticancer drugs, such as their low bioavailability, poor targeting efficacy, and serious side effects, have led to the discovery of new therapeutic agents and potential drug delivery systems. In particular, the introduction of nano-sized drug delivery systems (NDDSs) has opened new horizons for effective cancer treatment. These are considered potential systems that provide deep tissue penetration and specific drug targeting. On the other hand, nuclear factor erythroid 2-related factor 2 (NRF2)-based anticancer treatment approaches have attracted tremendous attention and produced encouraging results. However, the lack of effective formulation strategies is one of the factors that hinder the clinical application of NRF2 modulators. In this review, we initially focus on the critical role of NRF2 in cancer cells and NRF2-based anticancer treatment. Subsequently, we review the preparation and characterization of NDDSs encapsulating NRF2 modulators and discuss their potential for cancer therapy.

Ključne besede

NRF2 modulators;anticancer agents;nanoparticles;drug delivery;drug targeting;

Podatki

Jezik: Angleški jezik
Leto izida:
Tipologija: 1.02 - Pregledni znanstveni članek
Organizacija: UL FFA - Fakulteta za farmacijo
UDK: 620.3:616-006-085
COBISS: 61560579 Povezava se bo odprla v novem oknu
ISSN: 2076-3921
Št. ogledov: 169
Št. prenosov: 36
Ocena: 0 (0 glasov)
Metapodatki: JSON JSON-RDF JSON-LD TURTLE N-TRIPLES XML RDFA MICRODATA DC-XML DC-RDF RDF

Ostali podatki

Sekundarni jezik: Slovenski jezik
Sekundarne ključne besede: nanodelci;NRF modulatorji;terapevtska uporaba zdravil;zdravljenje raka;Rak (medicina);Tarčno zdravljenje;Nanotehnologija;
Vrsta dela (COBISS): Članek v reviji
Strani: str. 1-20
Letnik: ǂVol. ǂ10
Zvezek: ǂIss. ǂ5
Čas izdaje: 2021
DOI: 10.3390/antiox10050685
ID: 14704360