Regulation of oxygen homeostasis at the intestinal epithelial barrier site

Špela Konjar (Avtor), Miha Pavšič (Avtor), Marc Veldhoen (Avtor)

Povzetek

The unique biology of the intestinal epithelial barrier is linked to a low baseline oxygen pressure (pO$_2$), characterised by a high rate of metabolites circulating through the intestinal blood and the presence of a steep oxygen gradient across the epithelial surface. These characteristics require tight regulation of oxygen homeostasis, achieved in part by hypoxia-inducible factor (HIF)-dependent signalling. Furthermore, intestinal epithelial cells (IEC) possess metabolic identities that are reflected in changes in mitochondrial function. In recent years, it has become widely accepted that oxygen metabolism is key to homeostasis at the mucosae. In addition, the gut has a vast and diverse microbial population, the microbiota. Microbiome–gut communication represents a dynamic exchange of mediators produced by bacterial and intestinal metabolism. The microbiome contributes to the maintenance of the hypoxic environment, which is critical for nutrient absorption, intestinal barrier function, and innate and/or adaptive immune responses in the gastrointestinal tract. In this review, we focus on oxygen homeostasis at the epithelial barrier site, how it is regulated by hypoxia and the microbiome, and how oxygen homeostasis at the epithelium is regulated in health and disease.

Ključne besede

kisik;mitohondriji;hipoksija;mikrobiota;bolezni črevesja;oxygen;mitochondria;hypoxia;microbiota;IBD;

Podatki

Jezik:	Angleški jezik
Leto izida:	2021
Tipologija:	1.02 - Pregledni znanstveni članek
Organizacija:	UL FKKT - Fakulteta za kemijo in kemijsko tehnologijo
UDK:	577.2:616.34
COBISS:	74311427
ISSN:	1422-0067
Št. ogledov:	132
Št. prenosov:	49
Ocena:	0 (0 glasov)
Metapodatki:

Ostali podatki

Sekundarni jezik:	Slovenski jezik
Sekundarne ključne besede:	kisik;mitohondriji;hipoksija;mikrobiota;bolezni črevesja;
Vrsta dela (COBISS):	Članek v reviji
Strani:	str. 1-15
Letnik:	ǂVol. ǂ22
Zvezek:	ǂiss. ǂ17
Čas izdaje:	Sep. 2021
DOI:	10.3390/ijms22179170
ID:	14808617