ǂThe ǂonset of depression in middle-aged presumed healthy slovenian family practice attendees and its associations with genetic risk assessment, quality of life and health status

ǂa ǂcontribution for family medicine practitioners' early detection

Nina Jerala (Avtor), Polona Selič (Avtor)

Povzetek

Despite depression being a major driver of morbidity and mortality, the majority of primary care patients remain undiagnosed, so this study aimed to assess the prevalence of depression and the association with demographic and clinical variables, genetic risk, and quality of life. The participants were presumably healthy model family medicine practice (MFMP) attendees between 30 and 65 years of age and recruited during a preventive check-up in 2019. Each of the 40 pre-selected MFMP pragmatically invited 30 attendees to voluntarily participate. They completed a questionnaire of demographic, clinical, and social determinants, as well as a three-generational family history. The results were analyzed using multivariable modelling to calculate the associations with signs of depression. A modified Scheuner method was used to calculate the level genetic risk level using family history. Of 968 participants, aged 42.8 +- 8.6 years, 627 (64.8%) were women. The prevalence of depression was 4.1%. Signs of depression were negatively associated with health-related quality of life score, in particular in the domains of self-care (p = 0.001) and anxiety/depression (p < 0.001). Depression was also associated with predicted high risk for comorbidities given the family history (p = 0.030). Primary care directed at improving patients' quality of life should implement more widespread screening for mental health disorders. Family history for disease even beyond depression can be used by physicians as an important primary prevention tool.

Ključne besede

depression;mental health;quality of life;

Podatki

Jezik:	Angleški jezik
Leto izida:	2021
Tipologija:	1.01 - Izvirni znanstveni članek
Organizacija:	UL MF - Medicinska fakulteta
UDK:	616.89
COBISS:	72124931
ISSN:	1660-4601
Št. ogledov:	108
Št. prenosov:	48
Ocena:	0 (0 glasov)
Metapodatki:

Ostali podatki

Sekundarni jezik:	Slovenski jezik
Sekundarne ključne besede:	depresija;duševno zdravje;kakovost življenja;
Vrsta dela (COBISS):	Članek v reviji
Strani:	str. 1-13
Letnik:	ǂVol. ǂ18
Zvezek:	ǂiss. ǂ15
Čas izdaje:	2021
DOI:	10.3390/ijerph18158197
ID:	14900691