Jeel Raval (Avtor), Ekaterina Gongadze (Avtor), Metka Benčina (Avtor), Ita Junkar (Avtor), Niharika Rawat (Avtor), Luka Mesarec (Avtor), Veronika Kralj-Iglič (Avtor), Wojciech Góźdź (Avtor), Aleš Iglič (Avtor)

Povzetek

In this review paper, we theoretically explain the origin of electrostatic interactions between lipid bilayers and charged solid surfaces using a statistical mechanics approach, where the orientational degree of freedom of lipid head groups and the orientational ordering of the water dipoles are considered. Within the modified Langevin Poisson–Boltzmann model of an electric double layer, we derived an analytical expression for the osmotic pressure between the planar zwitterionic lipid bilayer and charged solid planar surface. We also show that the electrostatic interaction between the zwitterionic lipid head groups of the proximal leaflet and the negatively charged solid surface is accompanied with a more perpendicular average orientation of the lipid head-groups. We further highlight the important role of the surfaces’ nanostructured topography in their interactions with biological material. As an example of nanostructured surfaces, we describe the synthesis of TiO$_2$ nanotubular and octahedral surfaces by using the electrochemical anodization method and hydrothermal method, respectively. The physical and chemical properties of these nanostructured surfaces are described in order to elucidate the influence of the surface topography and other physical properties on the behavior of human cells adhered to TiO$_2$ nanostructured surfaces. In the last part of the paper, we theoretically explain the interplay of elastic and adhesive contributions to the adsorption of lipid vesicles on the solid surfaces. We show the numerically predicted shapes of adhered lipid vesicles corresponding to the minimum of the membrane free energy to describe the influence of the vesicle size, bending modulus, and adhesion strength on the adhesion of lipid vesicles on solid charged surfaces.

Ključne besede

elektrostatski lipidni dvosloj;zwitterionski lipidni dvosloj;električni dvojni sloj;osmotski tlak;svobodna orientacijska stopnja lipidnih skupin;orientirano urejanje vodnih dipolov;adhezija lipidnih veziklov;elastičnost lipidnih dvoslojev;oblike lipidnh veziklov;lipid bilayer electrostatics;zwitterionic lipid bilayers;electric double layer;osmotic pressure;orientational degree of freedom of lipid headgroups;orientational ordering of water dipoles;adhesion of lipid vesicles;lipid bilayer elasticity;lipid vesicle shapes;

Podatki

Jezik: Angleški jezik
Leto izida:
Tipologija: 1.02 - Pregledni znanstveni članek
Organizacija: UL FE - Fakulteta za elektrotehniko
UDK: 577
COBISS: 70365955 Povezava se bo odprla v novem oknu
ISSN: 2077-0375
Št. ogledov: 127
Št. prenosov: 46
Ocena: 0 (0 glasov)
Metapodatki: JSON JSON-RDF JSON-LD TURTLE N-TRIPLES XML RDFA MICRODATA DC-XML DC-RDF RDF

Ostali podatki

Sekundarni jezik: Slovenski jezik
Sekundarne ključne besede: elektrostatski lipidni dvosloj;zwitterionski lipidni dvosloj;električni dvojni sloj;osmotski tlak;svobodna orientacijska stopnja lipidnih skupin;orientirano urejanje vodnih dipolov;adhezija lipidnih veziklov;elastičnost lipidnih dvoslojev;oblike lipidnh veziklov;
Vrsta dela (COBISS): Članek v reviji
Strani: str. 1-20
Letnik: ǂiss. ǂ7
Zvezek: 533
Čas izdaje: Jul. 2021
DOI: 10.3390/membranes11070533
ID: 14956888