Youngsun T. Cho (Avtor), Flora Moujaes (Avtor), Charles H. Schleifer (Avtor), Martina Starc (Avtor), Jie Lisa Ji (Avtor), Nicole Santamauro (Avtor), Alan Anticevic (Avtor), Brendan D. Adkinson (Avtor), Antonija Kolobaric (Avtor), Morgan Flynn (Avtor), John Harrison Krystal (Avtor), John D. Murray (Avtor), Grega Repovš (Avtor)

Povzetek

Integrating motivational signals with cognition is critical for goal-directed activities. The mechanisms that link neural changes with motivated working memory continue to be understood. Here, we tested how externally cued and non-cued (internally represented) reward and loss impact spatial working memory precision and neural circuits in human subjects using fMRI. We translated the classic delayed-response spatial working memory paradigm from non-human primate studies to take advantage of a continuous numeric measure of working memory precision, and the wealth of translational neuroscience yielded by these studies. Our results demonstrated that both cued and non-cued reward and loss improved spatial working memory precision. Visual association regions of the posterior prefrontal and parietal cortices, specifically the precentral sulcus (PCS) and intraparietal sulcus (IPS), had increased BOLD signal during incentivized spatial working memory. A subset of these regions had trial-by-trial increases in BOLD signal that were associated with better working memory precision, suggesting that these regions may be critical for linking neural signals with motivated working memory. In contrast, regions straddling executive networks, including areas in the dorsolateral prefrontal cortex, anterior parietal cortex and cerebellum displayed decreased BOLD signal during incentivized working memory. While reward and loss sim- ilarly impacted working memory processes, they dissociated during feedback when money won or avoided in loss was given based on working memory performance. During feedback, the trial-by-trial amount and valence of reward/loss received was dissociated amongst regions such as the ventral striatum, habenula and periaqueductal gray. Overall, this work suggests motivated spatial working memory is supported by complex sensory processes, and that the IPS and PCS in the posterior frontoparietal cortices may be key regions for integrating motivational signals with spatial working memory precision.

Ključne besede

nevroznanost;kognicija;motivacija;delovni spomin;prostorski spomin;nagrade;možgani;neurosciences;cognition;motivation;short term memory;spatial memory;rewards;brain;

Podatki

Jezik: Angleški jezik
Leto izida:
Tipologija: 1.01 - Izvirni znanstveni članek
Organizacija: UL FF - Filozofska fakulteta
UDK: 159.91:159.953.2
COBISS: 104618499 Povezava se bo odprla v novem oknu
ISSN: 1095-9572
Št. ogledov: 95
Št. prenosov: 46
Ocena: 0 (0 glasov)
Metapodatki: JSON JSON-RDF JSON-LD TURTLE N-TRIPLES XML RDFA MICRODATA DC-XML DC-RDF RDF

Ostali podatki

Sekundarni jezik: Slovenski jezik
Sekundarne ključne besede: nevroznanost;kognicija;motivacija;delovni spomin;prostorski spomin;nagrade;možgani;
Strani: str. 1-15
Zvezek: ǂVol. ǂ254
Čas izdaje: 2002
ID: 15278133