Potential of phenolic antioxidants

Iva Ružić (Avtor), Mojca Škerget (Avtor), Željko Knez (Avtor)

Povzetek

In vitro studies have shown a link between the consumption of food rich in (poly)phenols, especially flavonoids, and reduced risk of coronary heart diseases. Several flavonoids have been reported to prevent low density lipoprotein cholesterol oxidation in vitro. The aim of our work was to determine antioxidant and radical scavenging activity of flavonoids myricetin,quercetin, rutin, luteolin, apigenin, kaempferol, catechin, epicatechin and epigallocatechin gallate and to study the influence of chemical structure and flavonoid interactions on the ability to inhibit oxidation and scavenge free radicals. Two in vitro methods, i.e. oxidation of â-carotene in an emulsion system and DPPH (1,1-Diphenyl-2-picrylhydrazyl) radical scavenging assay, were applied. In addition, a review of in vivo studies that investigate the effectiveness of food flavonoids in reducing oxidative damage in human body was done and their results were analyzed and compared to in vitro results obtained in our laboratory. Although all tested flavonoids except apigenin showed strong antioxidant and antiradical properties in vitro, these findings can not be completely confirmed from the reviewed in vivo human studies since those results are sometimes contradictoryand inconsistent.

Ključne besede

phenolics;flavonoids;antioxidant activity;antiradical activity;

Podatki

Jezik:	Angleški jezik
Leto izida:	2010
Tipologija:	1.02 - Pregledni znanstveni članek
Organizacija:	UM FKKT - Fakulteta za kemijo in kemijsko tehnologijo
Založnik:	=Slovenian Chemical Society
UDK:	66
COBISS:	14214678
ISSN:	1318-0207
Št. ogledov:	883
Št. prenosov:	57
Ocena:	0 (0 glasov)
Metapodatki:

Ostali podatki

Sekundarni jezik:	Slovenski jezik
Sekundarni povzetek:	Epidemiološke študije kažejo, da ima konzumiranje živil bogatih s polifenoli, predvsem s flavonoidi, preventivni vpliv na koronarno srčno bolezen. Flavonoidi naj bi vplivali na zmanjšanje oksidacije LDL holesterola in vitro. Namen naše študije je bil določiti antioksidativno aktivnost in radikalsko reaktivnost flavonoidov kot so miricetin, kvercetin, rutin, luteolin, apigenin, kempferol, katehin, epikatehin in epikatehin galat ter preučiti vpliv kemijske strukture in interakcij na sposobnost inhibicije oksidacije in vezavo prostih radikalov. Uporabili smo dve in vitro metodi: oksidacijo β-karotena v emulziji in DPPH (1,1-Diphenyl-2-picrylhydrazyl) metodo. V zaključku smo podali pregled ter analizo in vivo študij antioksidativne učinkovitosti flavonoidov v človeškem telesu ter jih primerjali z rezultati naših in vitro raziskav. Čeprav so vsi testirani flavonoidi razen apigenina pokazali močne antioksidativne in antiradikalske lastnosti in vitro, se ti rezultati ne ujemajo popolnoma z in vivo študijami, ki so včasih protislovne in nedosledne.
Sekundarne ključne besede:	fenoli;flavonoidi;antioksidantske aktivnosti;antiradicalne aktivnosti;
URN:	URN:NBN:SI
Vrsta dela (COBISS):	Znanstveno delo
Strani:	str. 263-271
Letnik:	ǂVol ǂ57
Zvezek:	ǂno. ǂ2
Čas izdaje:	2010
ID:	1728863