Samo Guzelj (Avtor), Matjaž Weiss (Avtor), Bram Slütter (Avtor), Ruža Frkanec (Avtor), Žiga Jakopin (Avtor)

Povzetek

The success of vaccination with subunit vaccines often relies on the careful choice of adjuvants. There is great interest in developing new adjuvants that can elicit a cellular immune response. Here, we address this challenge by taking advantage of the synergistic cross-talk between two pattern recognition receptors: nucleotide-binding oligomerization-domain-containing protein 2 (NOD2) and Toll-like receptor 7 (TLR7). We designed two conjugated NOD2/TLR7 agonists, which showed potent immunostimulatory activities in human primary peripheral blood mononuclear cells and murine bone-marrow-derived dendritic cells. One of these, 4, also generated a strong antigen-specific immune response in vivo, with a Th1-polarized profile. Importantly, our study shows that novel NOD2/TLR7 agonists elicit sophisticated and fine-tuned immune responses that are inaccessible to individual NOD2 and TLR7 agonists.

Ključne besede

immunostimulatory activity;vaccines;immune responses;pattern recognition receptors;synthesis of NOD2 agonist;Toll-like receptor 7;

Podatki

Jezik: Angleški jezik
Leto izida:
Tipologija: 1.01 - Izvirni znanstveni članek
Organizacija: UL FFA - Fakulteta za farmacijo
UDK: 615.371:616-097
COBISS: 128189187 Povezava se bo odprla v novem oknu
ISSN: 1520-4804
Št. ogledov: 80
Št. prenosov: 65
Ocena: 0 (0 glasov)
Metapodatki: JSON JSON-RDF JSON-LD TURTLE N-TRIPLES XML RDFA MICRODATA DC-XML DC-RDF RDF

Ostali podatki

Sekundarni jezik: Slovenski jezik
Sekundarne ključne besede: imunostimulatorna aktivnost;imunski odziv;receptorji za prepoznavanje vzorcev;sinteza agonista NOD2;Tollu podoben receptor 7;Cepiva;Imunski odziv;
Vrsta dela (COBISS): Članek v reviji
Strani: str. 15085–15101
Letnik: ǂVol. ǂ65
Zvezek: ǂno. ǂ22
Čas izdaje: 2022
DOI: 10.1021/acs.jmedchem.2c00808
ID: 17361110