Optimization of electrode position and electric pulse amplitude in electrochemotherapy

Anže Županič (Avtor), Selma Čorović (Avtor), Damijan Miklavčič (Avtor)

Povzetek

Background. In addition to the chemotherapeutic drug being present within the tumor during electric pulse delivery, successful electrochemotherapy requires the entire tumor volume to be subjected to a sufficiently high electric field,while the electric field in the surrounding healthy tissue is as low as possible to prevent damage. Both can be achieved with appropriate positioning of the electrodes and appropriate amplitude of electric pulses. Methods. We used 3D finite element numerical models and a genetic optimization algorithm to determine the optimum electrode configuration and optimum amplitude of electric pulses for treatment of three subcutaneous tumor models of different shapes and sizes and a realistic brain tumor model acquired from medical images. Results. In all four tumor cases, parallel needle electrode arrays were a better choice than hexagonal needle electrode arrays, since their utilization required less electric current and caused less healthy tissue damage. In addition, regardless of tumor geometry or needle electrode configuration, the optimum depth of electrode insertion was in all cases deeper than the deepest part of the tumor. Conclusions. Our optimization algorithm was able to determine the best electrode configuration in all four presented models and with further improvement it could be a useful tool in clinical electrochemotherapy treatment planning.

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Podatki

Jezik:	Angleški jezik
Leto izida:	2008
Tipologija:	1.01 - Izvirni znanstveni članek
Organizacija:	OI - Onkološki inštitut Ljubljana
Založnik:	Association of Radiology and Oncology
UDK:	616-006
COBISS:	24489945
ISSN:	1318-2099
Matična publikacija:	Radiology and oncology
Št. ogledov:	17
Št. prenosov:	4
Ocena:	0 (0 glasov)
Metapodatki:

Ostali podatki

Sekundarni jezik:	Slovenski jezik
Sekundarni naslov:	Optimizacija položaja elektrod in amplitude električnih pulzov v elektrokemoterapija
Sekundarne ključne besede:	Neoplasms;Therapy;Drug Therapy;Electroporation;Electrodes;Models, Theoretical;Elektrode;Elektroporacija;Novotvorbe;Modeli teoretski;
URN:	URN:NBN:SI
Komentar vira:	BSDOCID139559;
Strani:	str. 93-101
Letnik:	ǂLetn. ǂ42
Zvezek:	ǂšt. ǂ2
Čas izdaje:	2008
ID:	23111345