Irena Oblak (Avtor), Primož Petrič (Avtor), Franc Anderluh (Avtor), Vaneja Velenik (Avtor), Albert-Peter Fras (Avtor)

Povzetek

Background. The aim of the retrospective study was to evaluate the effectiveness and toxicity of radiochemotherapy in patients with squamous cellcarcinoma of the anal canal treated at a single institution. Patients and methods. Between 1/2003 and 9/2010, 84 patients were treated with radical radiochemotherapy at the Institute of Oncology Ljubljana, Slovenia. The treatment consisted of 3-dimensional conformal external beam radiotherapy with concurrent chemotherapy (5-fluorouracil and mytomycin C), followed by brachytherapy or external beam boost. The toxicity of therapy and its effectiveness were assessed. Results. The treatment was completed according tothe protocol in 79.8% of patients. The median follow-up time of 55 survivors was 53 months (range: 16-105 months). The 5-year locoregional control(LRC), disease-free survival (DFS), disease-specific survival (DSS), overall survival (OS) and colostomy-free survival (CFS) rates were 71%, 68%, 81%, 67% and 85%, respectively. No treatment-related mortality was observed. The most frequent acute side-effect of the treatment was radiodermatitis (grade 3-4 in 58.2% of patients). LENT-SOMA grade 3-4 late radiation side effects were observed in 15 (18%) patients. In patients with brachytherapy boost a trend of less late side effects was observed compared to patients with external beam boost (P=0.066). On multivariate analysis, complete clinicaldisease response was identified as an independent prognostic factor for LRC, DFS and DSS, the salvage surgery for LRC and DFS, whereas Hb below 120 g/l retained its independent prognostic value for OS. Conclusions. Radiochemotherapy provides an excellent disease control and the survival with preserving anal sphincter function in majority of patients. Surgical salvage with abdominoperineal resection for persistent or recurrent disease has curative potential.

Ključne besede

anus;Anus neoplasms;Combined modality therapy;radiološko zdravljenje;rak (medicina);Survival analysis;Therapy;Treatment outcome

Podatki

Jezik: Angleški jezik
Leto izida:
Tipologija: 1.01 - Izvirni znanstveni članek
Organizacija: OI - Onkološki inštitut Ljubljana
Založnik: Association of Radiology and Oncology
UDK: 616.35-006.6-08
COBISS: 1290619 Povezava se bo odprla v novem oknu
ISSN: 1318-2099
Matična publikacija: Radiology and oncology
Št. ogledov: 19
Št. prenosov: 3
Ocena: 0 (0 glasov)
Metapodatki: JSON JSON-RDF JSON-LD TURTLE N-TRIPLES XML RDFA MICRODATA DC-XML DC-RDF RDF

Ostali podatki

Sekundarni jezik: Slovenski jezik
Sekundarni naslov: Dolgoročni rezultati kombiniranega zdravljenja raka analnega kanala
Sekundarne ključne besede: Anus neoplasms;Therapy;Combined modality therapy;Treatment outcome;Survival analysis;
Vrsta dela (COBISS): Delo ni kategorizirano
Komentar vira: Soavtorji: Primož Petrič, Franc Anderluh, Vaneja Velenik, Peter Albert Fras;
Strani: str. 145-152, IV
Letnik: ǂVol. ǂ46
Zvezek: ǂno. ǂ2
Čas izdaje: Jun. 2012
DOI: 10.2478/v10019-012-0022-2
ID: 23196536