Tanja Marinko (Avtor), Jure Dolenc (Avtor), Cvetka Bilban-Jakopin (Avtor)

Povzetek

Background. Trastuzumab therapy given in combination with one of several chemotherapy regimens is currently considered the standard of care for the treatment of early-stage, human epidermal growth factor receptor-2 (HER2) -positive breast cancer. The treatment with trastuzumab is due to a significant impact on the survival part of the standard adjuvant treatment of patients with HER2-positive breast cancer. Patients treated with postoperative breast or chest wall irradiation receive trastuzumab concomitant with radiotherapy. In a small proportion of patients trastuzumab causes cardiotoxicity. Preclinical findings indicate a radiosensibilizing effect of trastuzumab in breast cancer cells, but it is not yet clear whether it radiosensibilizes cells of healthy tissues too.Conclusions. Special attention is required when left breast or left thoracic wall is irradiated in patient receiving trastuzumab, because long-term effects of the concurrent treatment with trastuzumab and radiotherapy are not yet known. In an era where more patients are surviving a diagnosis of breast cancer, better understanding and earlier detection of therapy-induced cardiac toxicity will be of paramount importance.

Ključne besede

radiotherapy;cardiotoxicity;trastuzumab;early breast cancer;

Podatki

Jezik: Angleški jezik
Leto izida:
Tipologija: 1.01 - Izvirni znanstveni članek
Organizacija: OI - Onkološki inštitut Ljubljana
Založnik: Association of Radiology and Oncology
UDK: 618.19-006-08
COBISS: 1686139 Povezava se bo odprla v novem oknu
ISSN: 1318-2099
Matična publikacija: Radiology and oncology
Št. ogledov: 19
Št. prenosov: 4
Ocena: 0 (0 glasov)
Metapodatki: JSON JSON-RDF JSON-LD TURTLE N-TRIPLES XML RDFA MICRODATA DC-XML DC-RDF RDF

Ostali podatki

Sekundarni jezik: Slovenski jezik
Sekundarne ključne besede: radioterapija;kardiotoksičnost;dojke;rak (medicina);
Vrsta dela (COBISS): Delo ni kategorizirano
Strani: str. 105-112, I
Letnik: ǂVol. ǂ48
Zvezek: ǂno. ǂ2
Čas izdaje: Jun. 2014
DOI: 10.2478/raon-2013-0040
ID: 23403409