Povzetek

Glioblastoma is the most aggressive and malignant primary brain tumor in adults and has a poor patient survival of only 20 months after diagnosis. This poor patient survival is at least partly caused by glioblastoma stem cells (GSCs), which are slowly-dividing and therefore therapy-resistant. GSCs are localized in protective hypoxic peri-arteriolar niches where these aforementioned stemness properties are maintained. We previously showed that hypoxic peri-arteriolar GSC niches in human glioblastoma are functionally similar to hypoxic peri-arteriolar hematopoietic stem cell (HSC) niches in human bone marrow. GSCs and HSCs express the receptor C-X-C receptor type 4 (CXCR4), which binds to the chemoattractant stromal-derived factor-1α (SDF-1α), which is highly expressed in GSC niches in glioblastoma and HSC niches in bone marrow. This receptor–ligand interaction retains the GSCs/HSCs in their niches and thereby maintains their slowly-dividing state. In acute myeloid leukemia (AML), leukemic cells use the SDF-1α–CXCR4 interaction to migrate to HSC niches and become slowly-dividing and therapy-resistant leukemic stem cells (LSCs). In this communication, we aim to elucidate how disruption of the SDF-1α–CXCR4 interaction using the FDA-approved CXCR4 inhibitor plerixafor (AMD3100) may be used to force slowly-dividing cancer stem cells out of their niches in glioblastoma and AML. Ultimately, this strategy aims to induce GSC and LSC differentiation and their sensitization to therapy.

Ključne besede

glioblastoma;matične celice;akutna mielonična levkemija;kostni mozeg;glioblastoma stem cells;niches;acute myeloid leukemia;hematopoietic stem cells;bone marrow;C-X-C receptor type 4;stromal-derived factor-1 ▫$[alpha]$▫;plerixafor;

Podatki

Jezik: Angleški jezik
Leto izida:
Tipologija: 1.03 - Kratki znanstveni prispevek
Organizacija: NIB - Nacionalni inštitut za biologijo
UDK: 577
COBISS: 40521221 Povezava se bo odprla v novem oknu
ISSN: 2079-7737
Št. ogledov: 43
Št. prenosov: 11
Ocena: 0 (0 glasov)
Metapodatki: JSON JSON-RDF JSON-LD TURTLE N-TRIPLES XML RDFA MICRODATA DC-XML DC-RDF RDF

Ostali podatki

Sekundarni jezik: Slovenski jezik
Sekundarne ključne besede: glioblastoma;matične celice;glioblastoma;akutna mielonična levkemija;kostni mozeg;
Komentar vira: Nasl. z nasl. zaslona; Opis vira z dne 30. 3. 2020;
Strani: str. 1-10
Letnik: ǂVol. ǂ9
Zvezek: ǂiss. ǂ31
Čas izdaje: 17 Feb. 2020
DOI: 10.3390/biology9020031
ID: 24670032