Gabrijela Tkalec (Avtor), Jan Rožanc (Avtor), Uroš Maver (Avtor), Matjaž Finšgar (Avtor), Željko Knez (Avtor), Zoran Novak (Avtor)

Povzetek

Developing double porous biodegradable and biocompatible scafolds that can incorporate and release drugs in a controlled manner holds immense potential in regenerative medicine. This study presents a synthesis method for preparing a macro-mesoporous scafold, where poly(lactic acid) adds to the macroporous region and mechanical properties, and ethyl cellulose adds to the surface area (182 m2 /g). High surface area enables the incorporation of model drug indomethacin with an entrapment efciency of 17.0% and its later controlled release profle. The resulting scafold has desirable mechanical properties in the range of a natural trabecular bone with a compressive modulus of 22.4 MPa. The material is stable in the simulated body fuids for 120 days before the slow degradation starts. In vitro studies demonstrate the material’s ability to support bone cell adhesion, proliferation, and diferentiation, promoting osteogenic activity. Overall, the unique combination of poly(lactic acid) and ethyl cellulose produces advanced materials with tailored macro and mesopore properties, remarkable mechanical properties, optimal degradation rate, and drug delivery potential, making it a promising candidate for bone scafolds in regenerative medicine and tissue engineering

Ključne besede

polimeri;poroznost;spektrometrija;bio composite;polymer-matrix composites (PMCs);polymers;porosity/voids;secondary ion mass spectrometry;

Podatki

Jezik: Angleški jezik
Leto izida:
Tipologija: 1.01 - Izvirni znanstveni članek
Organizacija: UM FKKT - Fakulteta za kemijo in kemijsko tehnologijo
Založnik: Springer Link
UDK: 66.02
COBISS: 192685315 Povezava se bo odprla v novem oknu
ISSN: 1572-882X
Št. ogledov: 28
Št. prenosov: 1
Ocena: 0 (0 glasov)
Metapodatki: JSON JSON-RDF JSON-LD TURTLE N-TRIPLES XML RDFA MICRODATA DC-XML DC-RDF RDF

Ostali podatki

Sekundarni jezik: Slovenski jezik
Sekundarne ključne besede: polimeri;poroznost;spektrometrija;
Vrsta dela (COBISS): Članek v reviji
Strani: 19 str.
Čas izdaje: Published online: 13 April 2024
DOI: 10.1007/s10570-024-05905-w
ID: 24798343