Translational regulation in hepatocellular carcinogenesis

Suzana Bračič (Avtor), Christoph Schatz (Avtor), Johannes Haybaeck (Avtor)

Povzetek

The mortality of hepatocellular carcinoma (HCC) is distributed unevenly worldwide. One of the major causes is hepatitis B or hepatitis C virus infection and the development and progression of liver cirrhosis. The carcinogenesis of HCC is among others regulated via the mTOR (mechanistic target of rapamycin) signaling pathway and represents a possible method of targeted treatment. The aim of our article was to address the most recent clinical advances and findings of basic studies on the mTOR signaling pathway and the involved factors. Risk factors play a key role in dysregulation of the signaling pathway, where both mTORCs are upregulated and protein synthesis is altered. eIFs and, to a lesser extent, eEFs play an essential role in this process. Whether the factor will be upregulated or downregulated, among others, depends on hepatitis B/C virus infection. The amount of a particular factor in a patient sample lets us know whether HCC recurrence will occur, what is the likelihood of chemoresistance, and what outcome is predicted for patients with an increased value. Our analysis shows that in addition to mTOR, eIF3, eIF4, and eIF5 play an important role, as they can serve as biomarkers for non- and virus-related HCC.

Ključne besede

mTOR;virus related HCC;non-virus related HCC;cancer;translation initiation;liver;

Podatki

Jezik:	Angleški jezik
Leto izida:	2021
Tipologija:	1.02 - Pregledni znanstveni članek
Organizacija:	UM MF - Medicinska fakulteta
Založnik:	Dovepress
UDK:	616.36-006
COBISS:	83680515
ISSN:	1177-8881
Št. ogledov:	0
Št. prenosov:	0
Ocena:	0 (0 glasov)
Metapodatki:

Ostali podatki

Sekundarni jezik:	Slovenski jezik
Sekundarne ključne besede:	Hepatocelularni karcinom;rak;povezava z virusom;začetek prevajanja;jetra;
Vrsta dela (COBISS):	Znanstveno delo
Strani:	str. 4359-4369
Zvezek:	ǂVol. ǂ15
Čas izdaje:	2021
DOI:	10.2147/DDDT.S255582
ID:	25325960